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首页> 外文期刊>Journal of neurology >Memory complaints in patients with normal cognition are associated with smaller hippocampal volumes.
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Memory complaints in patients with normal cognition are associated with smaller hippocampal volumes.

机译：认知能力正常的患者的记忆障碍与海马体积较小有关。

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摘要

We aimed to investigate volumetry of the medial temporal lobe in patients with subjective memory complaints without any cognitive impairment. This study included 20 patients with subjective memory complaints and normal cognitive function and 28 controls without memory complaints. Volumes of the hippocampus and parahippocampal gyrus (PHG) were measured using coronal T1-weighted MR images. Cognitive functions were assessed using the Cambridge Cognitive Examination. Depressive symptoms were assessed using the Geriatric Depression Scale. Differences between groups were analysed using t-tests. Patients with subjective memory complaints had a higher education and more depressive symptoms than controls ( p < 0.01). Moreover, they had smaller left hippocampal volumes than controls ( p < 0.01). There were no differences between groups in the volume of the right hippocampus or PHG. There was a moderate association between the volume of left hippocampus and left PHG and memory-score (r = 0.32, p = 0.03; r = 0.34,p = 0.02). We concluded that memory complaints in patients without any cognitive impairment were associated with smaller left hippocampal volumes and more depressive symptoms. These preliminary results suggest that memory complaints may reflect minimal brain deficits associated with impending dementia, depression or a combination of both disorders.
机译：我们旨在调查没有任何认知障碍的主观记忆障碍患者的内侧颞叶容积。这项研究包括20例主观记忆障碍且认知功能正常的患者和28例无记忆障碍的对照。使用冠状T1加权MR图像测量海马和海马旁回（PHG）的体积。使用剑桥认知考试评估认知功能。使用老年抑郁量表评估抑郁症状。使用t检验分析组之间的差异。有主观记忆障碍的患者比对照组的受教育程度更高，抑郁症状也更多（p <0.01）。而且，他们的左海马体积比对照组小（p <0.01）。两组之间右海马或PHG的体积无差异。左海马体和左PHG量与记忆分数之间存在中等关联（r = 0.32，p = 0.03; r = 0.34，p = 0.02）。我们得出的结论是，没有任何认知障碍的患者的记忆障碍与较小的左海马体积和更多的抑郁症状有关。这些初步结果表明，记忆力障碍可能反映了与即将发生的痴呆，抑郁症或两种疾病的合并症相关的最小的大脑缺陷。

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