...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of neurology >Greater improvement in quality of life following unilateral deep brain stimulation surgery in the globus pallidus as compared to the subthalamic nucleus.
【24h】

Greater improvement in quality of life following unilateral deep brain stimulation surgery in the globus pallidus as compared to the subthalamic nucleus.

机译：与丘脑下核相比，在苍白球单侧深部脑刺激手术后，生活质量有了更大的改善。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

While deep brain stimulation (DBS) surgery is a well-accepted treatment for Parkinson disease (PD) that improves overall quality of life (QoL), its effects across different domains of QoL are unclear. The study reported here directly compared the effects of unilateral DBS in subthalamic nucleus (STN) or globus pallidus (GPi) on QoL in 42 non-demented patients with medication-refractory PD. Patients were enrolled in the COMPARE trial, a randomized clinical trial of cognitive and mood effects of STN versus GPi DBS conducted at the University of Florida Movement Disorders Center. Patients underwent motor, mood, verbal fluency and QoL (Parkinson disease questionnaire: PDQ-39) measures before and 6 months following surgery. Groups experienced motor and mood improvements that did not differ by target. Patients with STN DBS evidenced a slight decrement on letter fluency. On average, all patients endorsed better overall QoL after surgery. However, despite similar motor and mood improvements, GPi patients improved more than STN patients (38 vs. 14%, respectively; P = 0.03). Patients reported better QoL on subscales of mobility, activities of daily living (ADLs), emotional well-being, stigma, cognition and discomfort, but not on those of social support and communication. Improvements on the mobility, ADLs, stigma and social support subscales were greater amongst GPi patients. In regression analyses, only depression changes independently predicted changes in overall QoL as well as emotional well-being and social support changes. Within the STN group only, declining category fluency scores correlated with poorer QoL on the communication subscale. Unilateral DBS in both STN and GPi improved QoL overall and in disparate domains 6 months after surgery. Patients receiving GPi DBS reported greater improvements that cannot be explained by differential mood or motor effects; however, verbal fluency changes may have partially contributed to lesser QoL improvements amongst STN patients.
机译：虽然深部脑刺激（DBS）手术是改善帕金森病（PD）的公认疗法，可改善整体生活质量（QoL），但其在QoL不同领域的作用尚不清楚。此处的研究报告直接比较了42例非药物性难治性PD非痴呆患者的丘脑底核（STN）或苍白球（GPi）单侧DBS对QoL的影响。患者参加了COMPARE试验，该试验是在佛罗里达大学运动失调中心进行的STN与GPi DBS认知和情绪影响的随机临床试验。术前和术后6个月对患者进行运动，情绪，言语流畅度和QoL（帕金森病问卷：PDQ-39）测量。小组的运动和情绪改善没有因目标而异。 STN DBS患者证明字母流畅度略有下降。平均而言，所有患者在手术后的总体生活质量均得到了较好的认可。然而，尽管在运动和情绪上有类似的改善，但GPi患者比STN患者的改善更大（分别为38％和14％; P = 0.03）。患者在活动能力，日常生活活动（ADL），情绪健康，污名，认知和不适等子量表上的生活质量更好，但在社会支持和沟通方面则没有。 GPi患者的活动能力，ADL，耻辱感和社会支持分量表的改善更大。在回归分析中，只有抑郁变化独立地预测了总体生活质量的变化，以及情绪健康和社会支持的变化。仅在STN组中，类别流利度得分的下降与沟通子量表上较差的QoL相关。术后6个月，STN和GPi中的单侧DBS改善了整体和不同领域的QoL。接受GPi DBS的患者报告有更大的改善，无法用不同的情绪或运动效果来解释;但是，口语流利度的变化可能部分导致STN患者的QoL改善较慢。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号