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首页> 外文期刊>Journal of neurology >MRI gray and white matter measures in progressive supranuclear palsy and corticobasal syndrome
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MRI gray and white matter measures in progressive supranuclear palsy and corticobasal syndrome

机译：进行性核上性麻痹和肾上腺皮质综合征的MRI灰色和白色物质测量

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摘要

We evaluated MRI measures of gray and white matter damages in 19 patients with progressive supranuclear palsy (PSP), 11 with corticobasal syndrome (CBS), and 14 healthy subjects (HS) to differentiate patients with PSP from those with CBS. We calculated surface-based maps of the cortical volume, cortical thickness, surface area, and voxel level maps of sub-cortical volume, and diffusion tensor imaging parameters using automated scripts implemented in FreeSurfer and FSL toolboxes. No significant differences in cortical volume loss were observed between PSP and CBS. When cortical volume was divided into cortical thickness and surface area, cortical thickness in peri-rolandic brain regions was significantly smaller in CBS than in PSP patients, whereas surface area was significantly smaller in PSP than HS. We also found widespread volume loss in sub-cortical structures in patients with PSP and CBS in comparison to HS. Both patient groups displayed diffusion tensor imaging abnormalities: compared to HS, widespread fractional anisotropy and radial diffusivity changes were observed in PSP, whereas axial and radial diffusivity changes were prominent in CBS. Mini-mental state examination positively correlated with diffusion changes in patients with PSP. In conclusion, cortical thickness, surface area, and diffusion tensor imaging parameters may be sensitive enough to help differentiate patients with PSP from those with CBS.
机译：我们评估了19例进行性核上性麻痹（PSP），11例肾上腺皮质综合征（CBS）和14例健康受试者（HS）的灰白质损害的MRI测量，以区分PSP患者和CBS患者。我们使用在FreeSurfer和FSL工具箱中实现的自动脚本，计算了皮质体积，皮质厚度，表面积和亚皮质体积的体素水平图以及扩散张量成像参数的基于表面的图。在PSP和CBS之间没有观察到皮质体积损失的显着差异。当将皮层体积分为皮层厚度和表面积时，CBS的rolandic大脑区域的皮层厚度显着小于PSP患者，而PSP的表面积显着小于HS。我们还发现，与HS相比，PSP和CBS患者的皮质下结构普遍存在体积损失。两组患者均表现出弥散张量成像异常：与HS相比，PSP中观察到广泛的分数各向异性和径向扩散率变化，而CBS中轴向和径向扩散率变化显着。轻度精神状态检查与PSP患者的扩散变化呈正相关。总之，皮层厚度，表面积和扩散张量成像参数可能足够灵敏，有助于区分PSP患者和CBS患者。

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