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首页> 外文期刊>Journal of neurology >Risk factors for tumor occurrence in patients with myasthenia gravis.
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Risk factors for tumor occurrence in patients with myasthenia gravis.

机译：重症肌无力患者肿瘤发生的危险因素。

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摘要

There is still uncertainty regarding risk factors for cancer occurrence in patients with myasthenia gravis (MG). The objective of this study is to determine the prevalence of extrathymic neoplasms in patients with MG and the factors associated with tumor occurrence. The archives of four tertiary MG centers were consulted and patients were interviewed on the main clinical features of the disease, the presence and type(s) of extrathymic neoplasms and other autoimmune disorders, and their symptomatic and immunosuppressant treatments (with detailed schedules). A retrospective cohort survey was undertaken comparing the demographic and clinical variables of patients with extrathymic neoplasms to those of the remaining MG population. 2,479 patients were traced and interviewed personally or through informants. The sample included 1,490 women and 989 men (mean age 54.7 years). Other autoimmune disorders were present in 216 cases (8.7%). Thymectomy was performed in 1,549 cases (62.5%), thymic hyperplasia and thymoma being the most common findings. Acetylcholinesterase-inhibitors were the most common treatment (93.5%), followed by steroids (64.3%), azathioprine (35.0%), plasma exchange (13.2%), immunoglobulins (7.5%), cyclosporine (5.3%), and cyclophosphamide (5.0%). 221 patients (8.9%) had one or more extrathymic tumors, 168 of which occurred after disease onset. Patients with and without extrathymic neoplasms were followed for 14.8 and 13.9 years, respectively. Variables shown by multivariate analysis to be associated with increased neoplastic risk included older age, thymoma and immunoglobulin use. Extrathymic tumors are a common finding in patients with MG and tend to be associated with age, thymoma, and immunoglobulin use.
机译：重症肌无力（MG）患者发生癌症的危险因素仍然不确定。这项研究的目的是确定MG患者胸腺肿瘤的患病率以及与肿瘤发生有关的因素。咨询了四个三级MG中心的档案，并就该疾病的主要临床特征，胸腺肿瘤和其他自身免疫性疾病的存在和类型以及对症和免疫抑制剂治疗（详细时间表）采访了患者。进行了一项回顾性队列研究，比较了胸腺外肿瘤患者与其余MG人群的人口统计学和临床​​变量。亲自或通过线人对2479名患者进行了追踪和采访。样本包括1,490名女性和989名男性（平均年龄54.7岁）。其他自身免疫性疾病也存在216例（8.7％）。胸腺切除术进行了1,549例（62.5％），胸腺增生和胸腺瘤是最常见的发现。乙酰胆碱酯酶抑制剂是最常见的治疗方法（93.5％），其次是类固醇（64.3％），硫唑嘌呤（35.0％），血浆置换（13.2％），免疫球蛋白（7.5％），环孢菌素（5.3％）和环磷酰胺（5.0） ％）。 221例患者（8.9％）患有一种或多种胸腺肿瘤，其中168例在疾病发作后发生。对有胸腺肿瘤和无胸腺肿瘤的患者分别进行了14.8年和13.9年的随访。多变量分析显示与肿瘤风险增加相关的变量包括年龄，胸腺瘤和免疫球蛋白的使用。胸腺外肿瘤是MG患者的常见发现，并往往与年龄，胸腺瘤和免疫球蛋白的使用有关。

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