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首页> 外文期刊>Journal of neurology >Significance of aortic atherosclerotic disease in possibly embolic stroke: 64-multidetector row computed tomography study.
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Significance of aortic atherosclerotic disease in possibly embolic stroke: 64-multidetector row computed tomography study.

机译：主动脉粥样硬化性疾病在可能栓塞性卒中中的意义：64排多排计算机断层扫描研究。

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摘要

The usefulness of 64-multidetector row computed tomography (MDCT) for the evaluation of aortic atherosclerotic disease (AAD), a potential source of cerebral emboli, has recently been suggested. We aimed to assess the significance of AAD by using MDCT in patients who are suspected to have had embolic stroke clinically or radiologically but without evident cardioembolic source (possibly embolic stroke, or PES). From 5/2007 to 10/2007, patients who were presented with acute ischemic stroke, met predefined criteria for PES, and underwent MDCT, were found in a prospective stroke registry (PES group). High-risk AAD was defined as thrombus, ulceration, and a >or=4 mm thickness of atherosclerotic plaque in the ascending aorta and aortic arch on MDCT. For comparison, patients who were hospitalized due to non-embolic stroke (NES) during the study period and who underwent MDCT for the purpose of screening of coronary artery disease were selected (NES group). Among a total of 336 patients with acute ischemic stroke, 57 (20.0%) satisfied the criteria for PES, and MDCT was performed in 50 of these 57 patients. One-hundred six patients were selected as the NES group. The PES group had significantly higher prevalence of high-risk AAD than the NES group did (38.0 vs. 13.2%, P < 0.01). The odds ratio of high-risk AAD was 4.03 (95% confidence interval, 1.81-8.98) and this result remained significant after adjustment for risk factors of atherosclerosis. This study suggests the etiologic role of aortic atherosclerosis detected by MDCT in patients who are assumed to have had embolic stroke but without evident embolic source.
机译：最近有人建议使用64排多排计算机断层扫描（MDCT）评估主动脉粥样硬化疾病（AAD）（一种可能的脑栓塞来源）。我们的目的是通过使用MDCT评估疑似临床或放射学上有栓塞性卒中但无明显心脏栓塞来源（可能是栓塞性卒中或PES）的患者，以评估AAD的意义。从5/2007到10/2007，在前瞻性卒中登记册（PES组）中发现了患有急性缺血性卒中，符合PES预定标准并接受MDCT的患者。高危AAD被定义为MDCT上升主动脉和主动脉弓内的血栓，溃疡和厚度大于或等于4毫米的动脉粥样硬化斑块。为了进行比较，选择了在研究期间因非栓塞性卒中（NES）住院并接受MDCT筛查冠状动脉疾病的患者（NES组）。在336例急性缺血性卒中患者中，有57例（20.0％）符合PES标准，在这57例患者中的50例中进行了MDCT。一百六十名患者被选为NES组。 PES组的高危AAD患病率明显高于NES组（38.0 vs. 13.2％，P <0.01）。高危AAD的比值比为4.03（95％置信区间为1.81-8.98），在调整了动脉粥样硬化的危险因素后，该结果仍然很显着。这项研究表明，MDCT检测出的主动脉粥样硬化在假定患有栓塞性中风但没有明显栓塞来源的患者中的病因学作用。

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