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首页> 外文期刊>Journal of neurology >Changes observed in multiple sclerosis using magnetic resonance imaging reflect a focal pathology distributed along axonal pathways.
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Changes observed in multiple sclerosis using magnetic resonance imaging reflect a focal pathology distributed along axonal pathways.

机译：使用磁共振成像在多发性硬化症中观察到的变化反映了沿轴突途径分布的局灶病理。

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摘要

Multiple sclerosis has long been recognized as a multifocal inflammatory demyelinating disease of the central nervous system. The fact that patients with multiple sclerosis can develop a secondary progressive phase of their disease which is resistant to anti-inflammatory therapies, together with the fact that brain atrophy can develop in patients with a relatively low volume of white matter lesions, has led to suggestions that multiple sclerosis may be a degenerative disease. However, primary degenerative disorders are not usually associated with recurrent episodes of inflammatory demyelination. Support for neurodegeneration in MS being associated with focal lesions comes from topographical mapping of the spatial relationship of axonal injury and tissue loss to lesions using advanced image analysis methods.
机译：长期以来，多发性硬化症被认为是中枢神经系统多灶性炎症性脱髓鞘疾病。多发性硬化症患者可以发展出对抗炎疗法有抵抗力的疾病的继发性进展期，以及白质病灶相对较少的患者可以出现脑萎缩这一事实，这导致了一些建议多发性硬化症可能是变性疾病。但是，原发性退行性疾病通常与炎症性脱髓鞘的复发无关。 MS与局灶性病变相关的神经变性的支持来自使用先进的图像分析方法对轴突损伤和组织损失与病变的空间关系进行地形图绘制。

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