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首页> 外文期刊>Journal of neurology >The place of perceptual analysis of dysarthria in the differential diagnosis of corticobasal degeneration and Parkinson's disease.
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The place of perceptual analysis of dysarthria in the differential diagnosis of corticobasal degeneration and Parkinson's disease.

机译:构音障碍的知觉分析在皮质基底变性和帕金森氏病的鉴别诊断中的地位。

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摘要

OBJECTIVE: To characterize the dysarthria in patients with corticobasal degeneration (CBD) and determine if analysis of speech in isolation helps to distinguish CBD patients from patients with Parkinson's disease (PD). METHODS: 60 subjects were assessed by means of perceptual analysis of speech: 15 patients with CBD, 15 patients with PD and 30 control subjects. A detailed profile was furnished with the help of 33 perceptual items. A global perceptual approach was used to classify patients by judges blind to the medical diagnosis. Rating scales were adapted to quantify the degree of spasticity and hypokinesia in the speech of each patient. RESULTS: Dysarthria was frequent in CBD even though it remained mild for a long period of time. Group analysis revealed the importance of temporal errors of speech control in CBD patients while voice disturbances were most frequent in PD patients. However, attempts to classify patients according to global perceptual analysis remained below a reasonable level of clinical acceptability. Finally, even though the widespread neuropathological changes suggest that deviant speech dimensions of several types of dysarthria might be found in CBD, evidence for a mixed dysarthria with presence of spastic elements could not be established. CONCLUSION: The findings support the view that even though perceptual analysis is mandatory in the management of dysarthric patients, it does not help in the clinical differential diagnosis of CBD.
机译:目的:鉴定糖皮质异常(CBD)患者的构音障碍,并确定语音分析是否有助于将CBD患者与帕金森病(PD)患者区分开。方法:通过语音感知分析评估了60名受试者:15名CBD患者,15名PD患者和30名对照受试者。在33个感性项目的帮助下提供了详细的资料。通过对医学诊断不了解的法官,采用全局感知方法对患者进行分类。调整评定量表以量化每位患者言语中的痉挛和运动不足的程度。结果:即使长时间保持轻度,CBD中的构音异常也很常见。小组分析显示,在CBD患者中语音控制的暂时性错误很重要,而在PD患者中语音干扰最常见。但是,根据总体知觉分析对患者进行分类的尝试仍低于合理的临床可接受水平。最后,即使广泛的神经病理学改变提示可能在CBD中发现几种类型的构音障碍的语音差异,也无法确定存在痉挛成分的混合构音障碍的证据。结论:这一发现支持这样的观点,即尽管在进行心律失常患者的治疗中必须进行知觉分析,但对CBD的临床鉴别诊断无济于事。

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