...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of neurology >The value of leukocyte adhesion molecules in patients after ischemic stroke.
【24h】

The value of leukocyte adhesion molecules in patients after ischemic stroke.

机译：缺血性卒中患者白细胞粘附分子的价值。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Leukocyte recruitment and inflammatory response play an important patho-physiologic role after cerebral ischemia. This study aimed to evaluate whether leukocyte adhesion molecules can predict clinical outcome in patients after ischemic stroke. We prospectively examined serial changes in p-selectin glycoprotein ligand-1 (PSGL-1), macrophage antigen-1 (Mac-1), and lymphocyte function-associated antigen-1 (LFA-1) expression by leukocyte subsets using flow cytometry at various time points in 65 acute ischemic stroke patients and 60 controls. PSGL-1 expression on neutrophils and monocytes was significantly higher from day 1 to 90 after stroke as compared with control subjects (p < 0.05). The expression of monocyte Mac-1, LFA-1, and neutrophil Mac-1 were also significantly increased on days 1 and 7 after stroke than in control subjects (p < 0.05). Neutrophil PSGL-1 expression on day 1 was significantly higher in patients with early neurologic deterioration (END) (p < 0.01). Monocyte Mac-1 expression positively correlated with National Institutes of Health Stroke Scale (NIHSS) scores on admission (p = 0.013, gamma = 0.318). Underlying disease of diabetes mellitus and NIHSS score on admission were independently associated with 3-month outcome. The expressions of leukocyte adhesion molecules on admission are significantly increased in patients with acute ischemic stroke. This study shows that higher neutrophil PSGL-1 expression on admission may imply a higher risk for END and that monocyte Mac-1 expression on admission reflects the severity of ischemic stroke on admission.
机译：脑缺血后白细胞募集和炎症反应起着重要的病理生理作用。这项研究旨在评估白细胞粘附分子是否可以预测缺血性卒中患者的临床结局。我们使用流式细胞仪检测了白细胞亚群中p-选择蛋白糖蛋白配体1（PSGL-1），巨噬细胞抗原1（Mac-1）和淋巴细胞功能相关抗原1（LFA-1）表达的系列变化。 65个急性缺血性卒中患者和60个对照组的不同时间点。与对照组相比，卒中后第1天至第90天，中性粒细胞和单核细胞上PSGL-1的表达显着升高（p <0.05）。中风后第1天和第7天，单核细胞Mac-1，LFA-1和嗜中性粒细胞Mac-1的表达也显着高于对照组（p <0.05）。患有早期神经系统恶化（END）的患者在第1天的中性粒细胞PSGL-1表达明显升高（p <0.01）。入院时单核细胞Mac-1表达与美国国立卫生研究院卒中量表（NIHSS）得分呈正相关（p = 0.013，γ= 0.318）。糖尿病的基础疾病和入院时NIHSS评分与3个月预后独立相关。急性缺血性卒中患者入院时白细胞粘附分子的表达明显增加。这项研究表明，入院时嗜中性粒细胞PSGL-1的较高表达可能提示发生END的风险较高，入院时单核细胞Mac-1的表达反映了入院时缺血性卒中的严重程度。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号