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首页> 外文期刊>Journal of neurology >Osteopontin predicts long-term functional outcome among ischemic stroke patients.
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Osteopontin predicts long-term functional outcome among ischemic stroke patients.

机译：骨桥蛋白可预测缺血性中风患者的长期功能结局。

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Osteopontin (OPN) is a multifunctional protein which has shown neuroprotective properties in animal models of cerebral ischemia. Nevertheless, its role in acute human stroke has not yet been established. Therefore, we aimed to determine human serum OPN level during acute ischemic stroke and its relationship with patient outcome. We measured OPN levels in 178 consecutive patients with a middle cerebral artery (MCA) occlusion who received fibrinolytic therapy and in 40 control subjects. OPN level was determined by an enzyme-linked immunosorbent assay (ELISA). Bad functional outcome was defined by modified Rankin Scale (mRS) score >2 at 3 months after stroke onset. A logistic regression analysis was performed to determine factors that could be independently associated with poor prognosis. OPN levels among stroke patients did not differ from the controls' OPN levels (16.65 vs. 17.83 ng/mL, p = 0.404). Interestingly, OPN level was increased among those patients who showed worse prognosis at 3 months (19.96 vs. 15.48 ng/mL, p = 0.040). In a logistic regression model, an OPN level >27.22 ng/mL was found to be an independent factor for a bad outcome (OR 5.01, 95% CI 1.60-15.72, p = 0.006) after adjusting for potential confounders. Those patients showing higher OPN levels before tPA administration displayed a worse prognosis compared to those with lower OPN levels. Further research is necessary to elucidate the role of OPN in ischemic stroke pathophysiology and validate OPN as a useful tool to predict long-term stroke outcome.
机译：骨桥蛋白（OPN）是一种多功能蛋白，在脑缺血的动物模型中显示出神经保护作用。然而，其在急性人类中风中的作用尚未确定。因此，我们旨在确定急性缺血性中风期间人血清OPN的水平及其与患者预后的关系。我们测量了178名接受纤溶治疗的连续大脑中动脉（MCA）阻塞患者和40名对照受试者的OPN水平。 OPN水平通过酶联免疫吸附测定（ELISA）确定。中风发作后3个月，改良的Rankin量表（mRS）评分> 2定义了不良的功能预后。进行逻辑回归分析以确定可能与不良预后相关的因素。脑卒中患者的OPN水平与对照组的OPN水平没有差异（16.65 vs. 17.83 ng / mL，p = 0.404）。有趣的是，在3个月后预后较差的患者中OPN水平升高（19.96 vs. 15.48 ng / mL，p = 0.040）。在逻辑回归模型中，在校正潜在混杂因素后，发现OPN水平> 27.22 ng / mL是不良结局的独立因素（OR 5.01，95％CI 1.60-15.72，p = 0.006）。与较低OPN水平的患者相比，tPA给药前显示较高OPN水平的患者预后较差。有必要进行进一步的研究以阐明OPN在缺血性中风病理生理中的作用，并验证OPN作为预测长期中风预后的有用工具。

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