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首页> 外文期刊>Journal of neurology >Chronic relapsing inflammatory optic neuropatfayt-a systematic review of 122 cases reported
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Chronic relapsing inflammatory optic neuropatfayt-a systematic review of 122 cases reported

机译：慢性复发性炎症性视神经炎-122例系统回顾

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Chronic relapsing inflammatory optic neuropathy (CRION) is an entity that was described in 2003. Early recognition of patients suffering from CRION is relevant because of the associated risk for blindness if treated inappropriately. It seems timely to have a clinical review on this recently defined entity. A systematic literature review, irrespective of language, retrieved 22 case series and single reports describing 122 patients with CRION between 2003 and 2013. We review the epidemiology, diagnostic workup, differential diagnosis, and treatment (acute, intermediate, and long term) in view of the collective data. These data suggest that CRION is a distinct nosological entity, which is seronegative for anti-aquaporin four auto-antibodies and recognized by and managed through its dependency on immuno-suppression. Revised diagnostic criteria are proposed in light of the data compromising a critical discussion of relevant limitations.
机译：慢性复发性炎症性视神经病变（CRION）于2003年被描述。对CRION患者的早期识别非常重要，因为如果治疗不当会导致失明。对这个最近定义的实体进行临床检查似乎是时候了。有系统的文献综述，不分语言，共检索了22个病例系列报告和单个报告，描述了2003年至2013年之间的122例CRION患者。我们回顾了流行病学，诊断检查，鉴别诊断和治疗（急性，中期和长期）集体数据。这些数据表明，CRION是一种独特的病原学实体，对抗水通道蛋白四个自身抗体具有血清阴性作用，并通过其对免疫抑制的依赖而得以识别和控制。鉴于数据危及有关局限性的讨论，提出了修订的诊断标准。

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