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首页> 外文期刊>Journal of neurology >Link between non-motor symptoms and cognitive dysfunctions in de novo, drug-naive PD patients.
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Link between non-motor symptoms and cognitive dysfunctions in de novo, drug-naive PD patients.

机译：初次使用药物的PD患者非运动症状与认知功能障碍之间的联系。

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Little is known about the relationship between cognitive dysfunctions and the non-motor complex in subjects with newly diagnosed untreated Parkinson's disease (PD). The aim of this study was to explore the association between non-motor symptoms (NMS) and cognitive dysfunctions in an incident cohort of de novo, drug-naive, PD patients. Sixty-six non-demented, early, untreated PD patients completed a semi-structured interview on NMS and a battery of neuropsychological tests that assess verbal memory, visuospatial abilities, and attention/executive functions. Scores were age- and education-corrected. Patients who failed at least two tests for each cognitive domain were diagnosed as having mild cognitive impairment (MCI). All but three (95.4%) PD patients complained of at least one NMS. A total of 37.8% was diagnosed with MCI. There was a relationship between sleep-NMS and cognitive dysfunctions. Specifically, both REM behavioral sleep disorders (RBD) and insomnia were associated with lower scores on several cognitive tests. Moreover, RBD was closely related to MCI. NMS and MCI are very common even in the early phase of PD, before patients are treated. Given the correlation between sleep disturbances and cognitive impairment, it is possible that sleep symptoms in PD patients might be considered as an early marker of dementia.
机译：对于新诊断为未经治疗的帕金森氏病（PD）的受试者，认知功能障碍与非运动复合体之间的关系知之甚少。这项研究的目的是探讨从无毒品天真的PD患者的队列研究中非运动症状（NMS）与认知功能障碍之间的关系。六十六名未痴呆，早期未接受治疗的PD患者完成了对NMS的半结构式访谈和一系列神经心理学测试，评估了语言记忆，视觉空间能力和注意/执行功能。分数经过年龄和教育程度的校正。每个认知域至少两项测试均未通过的患者被诊断为患有轻度认知障碍（MCI）。除三名（95.4％）PD患者外，其余所有患者均抱怨至少一名NMS。总共诊断出MCI 37.8％。睡眠-NMS与认知功能障碍之间存在关联。特别是，REM行为睡眠障碍（RBD）和失眠都与一些认知测试的较低评分相关。此外，RBD与MCI密切相关。 NMS和MCI甚至在PD的早期阶段就很普遍，在接受治疗之前。考虑到睡眠障碍和认知障碍之间的相关性，PD患者的睡眠症状可能被视为痴呆的早期标志。

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