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首页> 外文期刊>Journal of neurology >Social-emotional dysfunction after isolated right anterior insular infarction.
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Social-emotional dysfunction after isolated right anterior insular infarction.

机译：孤立性右前岛梗塞后的社交情绪功能障碍。

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Dear Sirs,Recent human functional neuroimaging studies have demonstrated intrinsic functional connectivity among the anterior insula (AI), anterior cingulate cortex (ACC), amygdala, thalamus, hypothalamus, striatum, and brainstem. These regions have been collectively referred to as the "salience network" due to their consistent activation by diverse, homeostatically relevant stimuli that carry emotional weight [8]. Evidence supporting a role for the salience network in social-emotional function comes from patients with behavioral variant frontotemporal dementia (bvFTD), an early age-of-onset neurodegenerative disorder that produces dramatic changes in social behavior [6, 7]. The right ventral anterior insula, a focus of degeneration in bvFTD, has been proposed as a key hub within this network [9], and functional imaging studies reveal consistent activation of this region during social-emotional processing [3]. The consequences of isolated, destructive anterior insula lesions, however, have not been reported. Here, we describe a 66-year-old woman who developed an abrupt change in social behavior after isolated right ventral anterior insular infarction.
机译：亲爱的先生们：近期人类功能性神经影像学研究表明前岛（AI），前扣带回皮质（ACC），杏仁核，丘脑，下丘脑，纹状体和脑干之间存在内在的功能连通性。这些区域由于被承载情绪分量的各种稳态相关刺激一致地激活而被统称为“显着网络” [8]。支持显着网络在社会情感功能中发挥作用的证据来自行为变异额颞痴呆（bvFTD）患者，这是一种发病年龄较早的神经退行性疾病，会引起社会行为的巨大变化[6，7]。右腹前绝缘体是bvFTD变性的焦点，已被提议作为该网络内的关键枢纽[9]，功能成像研究显示该区域在社会情感过程中持续激活[3]。但是，尚未报告孤立的破坏性前岛损伤的后果。在这里，我们描述了一个66岁的女性，她在孤立的右腹前岛梗塞后发生了社交行为的突然变化。

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