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首页> 外文期刊>Journal of neurology >Tau haplotype affects CSF Tau levels in frontotemporal dementia : Implication for diagnostic purposes.
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Tau haplotype affects CSF Tau levels in frontotemporal dementia : Implication for diagnostic purposes.

机译：Tau单倍型影响额颞痴呆中的CSF Tau水平：对诊断目的具有影响。

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Sirs: Several lines of evidence have suggested a role of cerebrospinal (CSF) total-Tau (hTau) andphospho-Tau (pTau) levels as a diagnostic biomarker of help in early recognition and differentiation of degenerative dementias including frontotemporal dementia.High hTau and pTau levels are indeed elevated in FTD compared with control subjects, though reported values appear very widespread and do not correlate with disease severity . Explanations for such variability in FTD include clinical heterogeneity, different underlying pathogenetic mechanisms, and CSF sample storage conditions.In light of these findings, we analysed the effect of Tau haplotype segregation on CSF hTau and pTau levels. Epidemiological studies have demonstrated that there is no difference in Tau haplotype frequencies between FTD and normal controls, though in Progressive Supranuclear Palsy and Parkinson's Disease there is an increased frequency of HI-carriers. Indeed, it
机译：主席先生：有几条证据表明脑脊髓（CSF）总Tau（hTau）和磷酸Tau（pTau）的水平可作为诊断性生物标志物，有助于早期识别和区分退行性痴呆（包括额颞痴呆）.hTau和pTau高与报道的受试者相比，FTD的水平确实升高了，尽管报道的值似乎非常普遍，并且与疾病的严重程度无关。 FTD变异性的解释包括临床异质性，不同的潜在致病机制和CSF样品储存条件。根据这些发现，我们分析了Tau单倍型分离对CSF hTau和pTau水平的影响。流行病学研究表明，FTD和正常对照之间的Tau单倍型频率没有差异，尽管在进行性核上性麻痹和帕金森氏病中，HI携带者的频率增加。的确

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