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首页> 外文期刊>Journal of neurology >A comparison of neuropsychological deficits in primary and secondary progressive multiple sclerosis.
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A comparison of neuropsychological deficits in primary and secondary progressive multiple sclerosis.

机译：原发性和继发性进行性多发性硬化症中神经心理学缺陷的比较。

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摘要

Neuropsychological deficits and the relationship to brain pathology were examined in 13 primary progressive (PP) and 12 secondary progressive (SP) multiple sclerosis patients with a similar duration of the progressive phase and comparable physical disability. A battery of neuropsychological tests to assess attention, short-term and working memory was administered to the patients, and their performance was compared to that of 20 healthy controls matched for age and premorbid IQ. Total cerebral lesion load on T2-weighted magnetic resonance imaging was measured in the patients. Both PP and SP patients performed significantly worse than controls in most of the neuropsychological tests. There were only subtle differences between SP and PP on the working memory task although magnetic resonance imaging lesion load was significantly higher in SP than in PP patients. In this exploratory study only subtle differences in cognitive impairment were detected between SP and PP patients matched for physical disability and relevant illness features. The results also suggest that the severity of cognitive impairment cannot be fully explained by the extent of abnormalities detected on conventional T2-weighted magnetic resonance images, and that other pathological abnormalities such as in normal-appearing white matter are likely to be involved.
机译：在13名原发进行性（PP）和12名继发进行性（SP）多发性硬化症患者中检查了神经心理学缺陷及其与脑病理学的关系，这些患者具有相似的进展期持续时间和相当的身体残疾。对患者进行了一系列神经心理学测试，以评估其注意力，短期和工作记忆，并将他们的表现与年龄和病态智商相匹配的20名健康对照者进行比较。在患者中测量T2加权磁共振成像的总脑病变负荷。在大多数神经心理学测试中，PP和SP患者的表现均显着低于对照组。 SP和PP在工作记忆任务上只有细微的差别，尽管SP患者的磁共振成像损伤负荷明显高于PP患者。在这项探索性研究中，仅在因身体残疾和相关疾病特征而匹配的SP和PP患者之间发现了认知障碍的细微差异。结果还表明，认知障碍的严重程度不能完全由传统的T2加权磁共振图像上检测到的异常程度来解释，并且可能涉及其他病理异常，例如正常出现的白质。

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