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首页> 外文期刊>Journal of neurology >The effect of an APOE polymorphism on cognitive function depends on age
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The effect of an APOE polymorphism on cognitive function depends on age

机译：APOE多态性对认知功能的影响取决于年龄

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It remains controversial whether APOE E4 polymorphism is related to cognitive function in general population. We aimed to evaluate an association between the APOE ￡4 genotype and cognitive function, and whether this association may differ by age. Cognitive function was assessed using the Korean version of modified Mini-Mental State Examination (K-mMMSE) in 10,371 Koreans aged 45-74 years in Namwon City. According to the APOE ￡4 status, all participants were classified as non-carriers, heterozygotes, or homozygotes. Multiple linear and logistic regression models were used to evaluate the association between APOE genotypes and cognition. The frequency of APOE genotypes in the study population was 0.4, 10.1, 1.1, 72.9, 14.7 and 0.8 % for E2E2, E2E3, E2E4, E3E3, E3E4, and EAEA, respectively. Compared to the APOE ￡4 non-carriers, the heterozygotes and homozygotes showed 1.3 and 7.3 % lower K-mMMSE scores at 65-74 years and 0.8 and 4.6 % higher scores at 45-55 years, respectively. Educational attainment modified the effect of APOE ￡4 on cognitive function in the 45-54 age group (p for interaction =0.003), showing that the EA carriers with no-formal education showed significantly higher cognitive function than those with formal education. The present study demonstrates that the effect of APOE ￡4 on cognitive function depends on age and education.
机译：APOE E4基因多态性是否与普通人群的认知功能有关还存在争议。我们旨在评估APOE ￡ 4基因型与认知功能之间的关联，以及该关联是否可能因年龄而异。在韩国南原市，对10,371名年龄在45-74岁之间的韩国人进行了韩语版的改进的迷你精神状态检查（K-mMMSE），以评估其认知功能。根据APOE ￡ 4的状态，所有参与者都被分类为非携带者，杂合子或纯合子。多元线性和逻辑回归模型用于评估APOE基因型与认知之间的关联。对于E2E2，E2E3，E2E4，E3E3，E3E4和EAEA，研究人群中APOE基因型的频率分别为0.4、10.1、1.1、72.9、14.7和0.8％。与APOE ￡ 4非携带者相比，杂合子和纯合子在65-74岁时的K-mMMSE得分分别低1.3和7.3％，在45-55岁时的K-mMMSE得分分别高0.8和4.6％。教育程度改变了45-54岁年龄组APOE ￡ 4对认知功能的影响（交互作用p = 0.003），表明接受非正规教育的EA携带者的认知功能明显高于接受正规教育的EA携带者。本研究表明，APOE ￡ 4对认知功能的影响取决于年龄和受教育程度。

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