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首页> 外文期刊>Journal of neurology >Three-dimensional power-mode ultrasound for quantification of the progression of carotid artery atherosclerosis.
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Three-dimensional power-mode ultrasound for quantification of the progression of carotid artery atherosclerosis.

机译：三维功率模式超声用于量化颈动脉粥样硬化的进展。

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摘要

Elucidation of the dynamic nature of plaque progression has important implications for clinicians. The present study sought to establish an in vivo method for visualizing structural changes in carotid plaques. Three-dimensional reconstruction of parallel two-dimensional gray-scale B-mode ultrasound combined with power-mode examination of 38 carotid artery plaques was performed in a prospective study of 32 patients (18 men, 14 women; mean age 67.5 +/- 7.6 years). Initial mean plaque volume was 391 microl. After a mean of 18.9 months carotid artery plaque progression had occurred in 15% of carotid artery plaques, with plaque volume increasing 59% in these cases. Plaque volume remained constant, within a range of +/- 20% in 85% of cases. Progressive plaques were predominantly hypoechoic (3/5 cases) or had an ulcerated surface in cases of a hyperechoic echogenicity (2/5 cases). Risk factors and drug therapy were unrelated to plaque progression. This study illustrates that the combination of three-dimensional ultrasound with power-mode imaging improves the separation of the intraluminal plaque surface from the vessel lumen. Three-dimensional reconstruction of atherosclerotic carotid artery plaques enables the reproducible quantification of plaque volume and is therefore an excellent technique for longitudinal trials assessing progression or regression of carotid artery disease.
机译：阐明斑块进展的动态性质对临床医生具有重要意义。本研究试图建立一种可视化颈动脉斑块结构变化的体内方法。在一项针对32例患者（18例男性，14例女性;平均年龄67.5 +/- 7.6）的前瞻性研究中，进行了平行二维灰度B型超声的三维重建并结合了38种颈动脉斑块的功率模式检查年份）。初始平均噬菌斑体积为391微升。平均18.9个月后，颈动脉斑块中有15％发生了颈动脉斑块进展，在这些情况下，斑块体积增加了59％。斑块体积保持恒定，在85％的情况下在+/- 20％的范围内。进展性斑块主要是低回声（3/5例），或者在高回声回声性病例（2/5例）的表面有溃疡。危险因素和药物治疗与斑块进展无关。这项研究表明，三维超声与功率模式成像的结合可改善腔内斑块表面与血管腔的分离。动脉粥样硬化性颈动脉斑块的三维重建可实现斑块体积的可再现量化，因此是用于评估颈动脉疾病进展或消退的纵向试验的出色技术。

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