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首页> 外文期刊>Journal of neurology >The relationship between cortisol and verbal memory in the early stages of Huntington's disease.
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The relationship between cortisol and verbal memory in the early stages of Huntington's disease.

机译：亨廷顿舞蹈病早期阶段的皮质醇和言语记忆之间的关系。

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Hypothalamic pituitary adrenal (HPA) axis hyperactivity has been linked to learning and memory difficulties in a range of neurodegenerative and neuropsychiatric conditions. In Huntington's disease (HD), both declines in learning and memory and HPA axis dysfunction are present early in the disease. However, the relationship between specific learning and memory deficits and HPA axis functioning in HD has not been examined. The aim of this study was to investigate cortisol levels in relation to verbal learning and memory in pre-diagnosed (pre-HD) participants and patients at the early stages of diagnosed HD (early-HD). Cortisol concentration was assayed in saliva samples from 57 participants (17 early-HD, 20 pre-HD, and 20 controls) at four time-points across a 24-h period. Verbal memory was assessed using the California Verbal Learning Test-Second Edition (CVLT-II). We focused statistical analyses on the late evening cortisol concentration, and examined cortisol levels and verbal memory function in relation to diagnostic group (control, pre-HD, early-HD), and in a separate set of analyses combining pre-HD and early-HD (and excluding controls) we also examined cortisol and verbal memory performance in relation to the severity of HD-related motor signs. Of these two classification approaches, HD motor sign severity was more strongly associated with high evening cortisol levels and both reduced information encoding and memory retrieval. Separately, there was also a trend of higher cortisol levels in pre-HD. The findings suggest hypercortisolism and the underlying pathological changes may begin many years before a clinical diagnosis is made, but the memory decline associated with HPA axis disturbance may only become detectable once motor signs become pronounced.
机译：下丘脑垂体肾上腺（HPA）轴活动过度与一系列神经退行性疾病和神经精神病学条件下的学习和记忆困难有关。在亨廷顿舞蹈病（HD）中，学习和记忆力下降以及HPA轴功能障碍均在该疾病的早期出现。但是，尚未研究特定学习和记忆缺陷与HD中HPA轴功能之间的关系。这项研究的目的是调查在预诊断（HD前期）参与者和早期HD患者中，与言语学习和记忆有关的皮质醇水平。在24小时内的四个时间点，对来自57位参与者（17位早期HD，20位HD前和20位对照）的唾液样本中的皮质醇浓度进行了测定。使用加利福尼亚语言学习测试第二版（CVLT-II）评估语言记忆。我们将统计分析的重点放在了傍晚的皮质醇浓度上，并检查了与诊断组（对照组，HD前，HD早期）有关的皮质醇水平和言语记忆功能，以及结合HD前和早期HD的单独分析HD（和对照除外）我们还检查了与HD相关运动征象的严重程度有关的皮质醇和言语记忆表现。在这两种分类方法中，HD运动体征的严重程度与夜间皮质醇水平升高，信息编码和记忆检索减少均密切相关。另外，HD前期的皮质醇水平也有升高的趋势。研究结果表明，皮质醇过多症和潜在的病理变化可能在临床诊断之前就已经开始很多年了，但是与HPA轴紊乱相关的记忆力下降只有在运动征兆明显时才可以被发现。

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