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首页> 外文期刊>Journal of neurology >Acute disseminated encephalomyelitis: current controversies in diagnosis and outcome
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Acute disseminated encephalomyelitis: current controversies in diagnosis and outcome

机译：急性弥漫性脑脊髓炎：当前诊断和结果争议

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摘要

Acute disseminated encephalomyelitis (ADEM) is a rare inflammatory, demyelinating disorder of the CNS. Only in the past 15 years have larger groups of patients from several geographical areas been reported for comparisons across studies. In spite of the increased recognition of ADEM, the diagnosis of ADEM remains clinical, aided by neuroimaging confirmation, because of the lack of a biological marker. The diagnosis may be difficult, given that several diseases may present similar to ADEM. The controversial existence of multiphasic forms necessitates a continuous evaluation of the diagnosis by tracking subsequent events. Despite proposed consensus criteria, the diagnostic criteria employed to characterize ADEM range widely among the largest reported cohorts to date. This review comprehensively evaluates the current knowledge and controversies that surround ADEM, with special consideration of the distinction between ADEM and other demyelinating diseases such as multiple sclerosis. In addition, we present implications of the current knowledge of ADEM for both research and clinical practice.
机译：急性弥漫性脑脊髓炎（ADEM）是中枢神经系统的一种罕见的炎症性脱髓鞘疾病。仅在过去的15年中，才报道了来自几个地理区域的较大数量的患者群体，以进行研究之间的比较。尽管对ADEM的认识有所提高，但由于缺乏生物标记物，因此在神经影像学确认的帮助下，ADEM的诊断仍然是临床的。鉴于可能会出现与ADEM类似的几种疾病，因此诊断可能很困难。有争议的多相形式的存在需要通过跟踪后续事件来对诊断进行连续评估。尽管提出了共识标准，但迄今为止迄今最大的队列研究中，用来表征ADEM的诊断标准广泛存在。这篇综述全面评估了ADEM的当前知识和争议，并特别考虑了ADEM与其他多发性硬化症等脱髓鞘疾病之间的区别。此外，我们还介绍了ADEM当前知识对研究和临床实践的影响。

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