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Advances in leprosy immunology and the field application: A gap to bridge

机译：麻风病免疫学和现场应用的进展：弥合差距

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Advances concerning the hosts' immune response to Mycobacterium leprae infection have focused on elucidating the immune pathomechanisms involved, with the hope that predictive diagnostic and prognostic parameters (biomarkers) for field use would emerge; however, improvements in our understanding of the immunologic responses to this complex disease have, to date, somewhat failed to provide the effective and robust methods for improving its predictive diagnosis in the field situation, particularly in those patients suffering from paucibacillary disease. hi this contribution we have attempted to review some of the advances both in the immunology and immunopathology of leprosy, and also highlight the limited clusters of immune parameters that are now available. Most importantly, we point out the limitations that still prevail in the provision of effective biomarkers in the field situation for either: (1) the diagnosis of indeterminate disease, (2) predictive diagnosis of individuals developing reactional states, (3) monitoring efficacy of treatment, or (4) monitoring treatment of reactional states. (C) 2016 Elsevier Inc. All rights reserved.
机译：关于宿主对麻风分枝杆菌感染的免疫反应的研究进展集中在阐明所涉及的免疫病理机制上，希望能够出现用于田间使用的预测性诊断和预后参数（生物标志物）。然而，迄今为止，对我们对这种复杂疾病的免疫反应的理解的改善，在某种程度上未能提供有效和可靠的方法来改善其在现场情况下的预测诊断，特别是在那些患有脓杆菌病的患者中。在这一贡献中，我们试图回顾麻风病的免疫学和免疫病理学方面的一些进展，并且还强调了目前可用的免疫参数的局限性。最重要的是，我们指出了在以下情况下在提供有效生物标志物方面仍然存在的局限性：（1）不确定疾病的诊断，（2）预测反应状态发展的个体的诊断，（3）监测患者的疗效治疗，或（4）监测反应状态的治疗。 （C）2016 Elsevier Inc.保留所有权利。

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