...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >Thermodynamic and spectroscopic features of the behavior of amphotericin B in aqueous medium
【24h】

Thermodynamic and spectroscopic features of the behavior of amphotericin B in aqueous medium

机译：两性霉素B在水介质中的行为的热力学和光谱特征

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The interaction between amphotericin B molecules in aqueous medium solution was studied using absorption and circular dichroism approaches. The results showed that at concentrations below 1 #mu#M of amphotericin B, an equilibrium between the monomer and aggregate occured with a constant of approximately 0.6X10~6 M~(-1). The aggregate formation constant was dependent on the experimental conditions of the medium: its value increased at acidic aH values, while alkaline medium induced the equilibrium displacement to the monomer formation. Either neutral salts or chaotropic agents such as urea prevented the formation of the aggregate. The presence of net electrical charge on the amine and carboxyl groups plays a role in the thermodynamic stability of the aggregate. A hydrophobic effect was also found between the monomer form and the water molecules of neighbours. In the aggregate formation water molecules were released contributing to an increase in the entropic change.
机译：使用吸收和圆二色性方法研究了两性霉素B分子在水性介质溶液中的相互作用。结果表明，当两性霉素B的浓度低于1＃mu＃M时，单体与聚集体之间出现平衡，常数约为0.6X10〜6 M〜（-1）。聚集体形成常数取决于介质的实验条件：其值在酸性aH值下增加，而碱性介质则引起单体形成的平衡位移。中性盐或离液剂（例如尿素）均会阻止聚集体的形成。胺和羧基上净电荷的存在在聚集体的热力学稳定性中起作用。在单体形式和邻居的水分子之间也发现了疏水作用。在聚集体形成中，水分子被释放，导致熵变增加。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号