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首页> 外文期刊>Journal of Neuropathology and Experimental Neurology: Official Journal of the American Association of Neuropathologists, Inc >Characteristics of aquaporin expression surrounding senile plaques and cerebral amyloid angiopathy in Alzheimer disease
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Characteristics of aquaporin expression surrounding senile plaques and cerebral amyloid angiopathy in Alzheimer disease

机译：阿尔茨海默病老年斑周围水通道蛋白表达的特征和脑淀粉样血管病

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摘要

Senile plaques (SPs) containing amyloid β peptide (Aβ) 1-42 are the major species present in Alzheimer disease (AD), whereas Aβ1-40 is the major constituent of arteriolar walls affected by cerebral amyloid angiopathy. The water channel proteins astrocytic aquaporin 1 (AQP1) and aquaporin 4 (AQP4) are known to be abnormally expressed in AD brains, but the expression of AQPs surrounding SPs and cerebral amyloid angiopathy has not been described in detail. Here, we investigated whether AQP expression is associated with each species of Aβ deposited in human brains affected by either sporadic or familial AD. Immunohistochemical analysis demonstrated more numerous AQP1-positive reactive astrocytes in the AD cerebral cortex than in controls, located close to Aβ42-or Aβ40-positive SPs. In AD cases, however, AQP1-positive astrocytes were not often observed in Aβ-rich areas, and there was a significant negative correlation between the levels of AQP1 and Aβ42 assessed semiquantitatively. We also found that Aβ plaque-like AQP4 was distributed in association with Aβ42-or Aβ40-positive SPs and that the degree of AQP4 expression around Aβ40-positive vessels was variable. These findings suggest that a defined population of AQP1-positive reactive astrocytes may modify Aβ deposition in the AD brain, whereas the Aβ deposition process might alter astrocytic expression of AQP4.
机译：含有淀粉样β肽（Aβ）1-42的老年斑（SP）是阿尔茨海默病（AD）中存在的主要物种，而Aβ1-40是受脑淀粉样血管病影响的小动脉壁的主要成分。已知水通道蛋白星形细胞水通道蛋白1（AQP1）和水通道蛋白4（AQP4）在AD脑中异常表达，但是尚未详细描述SP周围AQP的表达和脑淀粉样血管病。在这里，我们调查了AQP表达是否与散发于家族性AD或家族性AD的人类大脑中沉积的Aβ的每种物种相关。免疫组织化学分析显示，与对照相比，AD大脑皮层中AQP1阳性的反应性星形胶质细胞多于对照，位于靠近Aβ42或Aβ40阳性SP的位置。然而，在AD病例中，在富含Aβ的区域中并不经常观察到AQP1阳性星形胶质细胞，并且半定量评估的AQP1和Aβ42水平之间存在显着的负相关。我们还发现，Aβ斑块状AQP4与Aβ42或Aβ40阳性SP伴有分布，并且AQP4在Aβ40阳性血管周围的表达程度是可变的。这些发现表明，确定的AQP1阳性反应性星形胶质细胞群可能会改变AD脑中的Aβ沉积，而Aβ沉积过程可能会改变AQP4的星形细胞表达。

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