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首页> 外文期刊>Journal of orthopaedic research >Early detection of bone infection and differentiation from post-surgical inflammation using 2-deoxy-2-(18F)-fluoro-D-glucose positron emission tomography (FDG-PET) in an animal model.
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Early detection of bone infection and differentiation from post-surgical inflammation using 2-deoxy-2-(18F)-fluoro-D-glucose positron emission tomography (FDG-PET) in an animal model.

机译：在动物模型中使用2-deoxy-2-（18F）-氟-D-葡萄糖正电子发射断层扫描（FDG-PET）早期检测骨感染和从术后炎症中分化。

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摘要

Diagnosing bone infection in the context of post-surgical inflammation is problematic since many of the early signs of infection are similar to normal post-surgical changes. We used a rabbit osteomyelitis model to evaluate the use of 2-deoxy-2-[(18)F]-fluoro-d-glucose positron emission tomography (FDG-PET) as a means of detecting post-operative infection in the context of post-surgical inflammation. Comparisons were made between infected and non-infected rabbits in which infection with Staphylococcus aureus was initiated at the time of surgery. Weekly PET scans were obtained 30 and 60 min after the introduction of FDG and analyzed based on standardized uptake values (SUV) at the surgical site and visual assessment of the presence or absence of infection. Concurrent X-rays were taken immediately prior to scanning. At 4weeks post-operatively, animals were sacrificed for histologic and bacteriologic confirmation of infection. Uptake of FDG was evident in the bone of all rabbits on day 1 post-surgery, however, SUV comparisons from the surgical site could not be used to distinguish between the infected and uninfected groups until day 15. Visual analysis of FDG-PET scans revealed a significant difference (p<0.01) between the infected and uninfected groups as early as day 8. This was due in part to the ability to visualize regional lymph nodes by FDG-PET.
机译：在手术后炎症的背景下诊断骨感染是有问题的，因为许多感染的早期迹象与正常的手术后变化相似。我们使用兔骨髓炎模型来评估2-脱氧-2-[（（18）F]-氟-d-葡萄糖正电子发射断层扫描（FDG-PET）的使用，作为检测术后感染的方法术后炎症。在感染和未感染的兔子之间进行比较，其中在手术时开始感染金黄色葡萄球菌。引入FDG后30和60分钟每周进行一次PET扫描，并根据手术部位的标准摄取值（SUV）以及肉眼评估感染的存在或不存在进行分析。扫描前立即拍摄并发X射线。术后4周，处死动物以进行组织学和细菌学确认感染。手术后第1天，所有兔子的骨骼中均吸收了FDG，但是直到第15天，才可通过手术部位的SUV比较来区分感染组和未感染组。早在第8天，感染组和未感染组之间的差异显着（p <0.01）。这部分归因于通过FDG-PET可视化区域淋巴结的能力。

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