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首页> 外文期刊>Journal of orthopaedic research >Assessment of healing of grade III posterolateral corner injuries: an in vivo model.
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Assessment of healing of grade III posterolateral corner injuries: an in vivo model.

机译:III级后外侧角损伤愈合的评估:一种体内模型。

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The primary purpose of this study was to test the hypothesis that an in vivo model of posterolateral knee instability could be created in the rabbit and to develop a natural history model in animals. The biomechanical and gross features of the rabbit knee 12 weeks after rupture of the fibular collateral ligament (FCL) and popliteus tendon were investigated in 14 skeletally mature New Zealand white rabbits. In the operated leg both the FCL and popliteus tendon were traumatically ruptured near their respective femoral insertions and the contralateral leg served as the control. At 12 weeks, the legs were removed for analysis of healing by both gross analysis and by biomechanical testing of knee joint stability. Biomechanical testing of varus-valgus knee rotation as well as concurrent coupled external rotation was performed to measure the amount of force necessary to produce a uniform amount of displacement. Grossly, only one of the FCLs and none of the popliteus tendons healed. Biomechanical testing revealed a statistically significant difference in the amount of force necessary to achieve 10 mm displacement for the operative versus the contralateral control knee for varus at 30 degrees ( [Formula: see text] ), 60 degrees ( [Formula: see text] ), and 90 degrees ( [Formula: see text] ). Our data supports the clinical observations of human grade III posterolateral corner (PLC) injuries, which appear to undergo minimal healing and generally result in poor outcomes with conservative treatment, that the FCL or popliteus tendon rarely heal when torn. This initial study of healing and knee stability after PLC injuries in rabbits supports the further study of in vivo animal models for evaluation of posterolateral knee injuries.
机译:这项研究的主要目的是检验以下假说:可以在兔子中创建后外侧膝关节不稳的体内模型,并在动物中建立自然历史模型。在14只骨骼成熟的新西兰白兔中,研究了腓骨侧副韧带(FCL)和pop肌腱断裂后12周的兔膝的生物力学和总体特征。在手术腿中,FCL和pop肌腱在各自的股骨插入处附近均受到创伤破裂,而对侧腿作为对照。在第12周,通过肉眼分析和膝关节稳定性的生物力学测试将腿部移开,以进行愈合分析。进行内外翻膝关节旋转以及同时发生的外部旋转的生物力学测试,以测量产生均匀位移量所需的力。总体而言,只有FCL之一,没有and肌腱愈合。生物力学测试显示,在30度(公式:参见文字),60度(公式:参见文字)内翻内窥镜手术中,与对侧对照膝关节达到10 mm位移所需的力量差异具有统计学意义。和90度([公式:请参见文字])。我们的数据支持了对人类III级后外侧角(PLC)损伤的临床观察,该损伤似乎受到最小程度的愈合,并且在保守治疗下通常导致较差的结果,即FCL或pop肌腱撕裂时很少愈合。兔PLC损伤后愈合和膝关节稳定性的初步研究支持了评估后外侧膝关节损伤的体内动物模型的进一步研究。

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