...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of orthopaedic research >Systemic and local ibandronate enhance screw fixation.
【24h】

Systemic and local ibandronate enhance screw fixation.

机译：全身和局部伊班膦酸盐可增强螺钉固定。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The trauma involved with inserting implants into bone leads to an activation of the inflammatory response and an activation of osteoclasts. In addition, apoptosis of osteocytes in the surrounding area has been implicated in further activation of osteoclasts. If the balance between resorption and bone formation shortly after implantation favours resorption, an impairment of early fixation might ensue. Because bisphosphonates inhibit resorption, this study analyses whether they can improve early fixation. Stainless steel screws (M 1.7) were inserted into the tibiae of 76 male Sprague-Dawley rats. Daily subcutaneous injections of ibandronate (3 microg) or saline were given to 20 rats. The remaining rats received ibandronate or saline directly applied into the drill hole before the screw was inserted. Tibiae were harvested at 14 days. Mechanical tests were performed on 50 tibiae. Systemically treated tibiae were tested for pull-out strength alone. Locally treated tibiae were tested for either pull-out or torque resistance. The remaining 18 tibiae were prepared for histology. Systemic ibandronate increased the pull-out force at failure by 30% ( [Formula: see text] ). Local treatment increased the force at failure by 15% ( [Formula: see text] ) and stiffness by 28% ( [Formula: see text] ). In the removal torque measurements, local ibandronate increased the torque-moment at failure by 60% ( [Formula: see text] ), and the maximum friction moment by 51% ( [Formula: see text] ). Energy for turning the screw 1/4 revolution was increased by 68% ( [Formula: see text] ). These results demonstrate that early remodeling events plays an important role in screw fixation, and that systemic or local bisphosphonate treatment could be an effective pharmacological path to improve early implant fixation.
机译：与将植入物插入骨中相关的创伤导致炎症反应的激活和破骨细胞的激活。此外，周围区域的破骨细胞凋亡与破骨细胞的进一步活化有关。如果植入后不久吸收与骨形成之间的平衡有利于吸收，则可能会导致早期固定受损。由于双膦酸盐抑制再吸收，因此本研究分析了它们是否可以改善早期固定。将不锈钢螺钉（M 1.7）插入76只雄性Sprague-Dawley大鼠的胫骨中。每天皮下注射伊班膦酸盐（3微克）或盐水至20只大鼠。其余的老鼠在螺钉插入之前将伊班膦酸盐或盐水直接加到钻孔中。在第14天收获胫骨。在50个胫骨上进行了机械测试。仅对全身治疗的胫骨的拔出强度进行了测试。对局部治疗的胫骨进行抗拔或抗扭力测试。其余的18条胫骨准备进行组织学检查。全身使用伊班膦酸盐可使失效时的拔出力增加30％（[公式：参见文字]）。局部处理使失效力增加了15％（公式），刚度增加了28％（公式）。在去除扭矩测量中，局部伊班膦酸盐使失效时的扭矩增加60％（公式），最大摩擦力矩增加51％（公式）。使螺钉旋转1/4转的能量增加了68％（[公式：请参见文本]）。这些结果表明，早期重塑事件在螺钉固定中起着重要作用，全身或局部双膦酸盐治疗可能是改善早期植入物固定的有效药理途径。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号