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首页> 外文期刊>Journal of orthopaedic research >Tensile properties of articular cartilage are altered by meniscectomy in a canine model of osteoarthritis.
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Tensile properties of articular cartilage are altered by meniscectomy in a canine model of osteoarthritis.

机译：在骨关节炎的犬模型中，半月板切除术改变了关节软骨的拉伸特性。

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Loss of or damage to the meniscus alters the pattern of loading in the knee joint and frequently leads to cartilage degeneration and osteoarthritis. The mechanical properties of articular cartilage have been shown to reflect the extent of cartilage degeneration in human osteoarthritis and in experimental models of joint disease, but there is little experimental data documenting changes in cartilage mechanics following meniscectomy. We hypothesized that the tensile properties of the surface zone of articular cartilage are altered following total medial meniscectomy. Twelve mongrel dogs underwent complete resection of the medial meniscus in the right knee, and the femoral cartilage was studied 12 weeks after the operation. We performed uniaxial, tensile stress-relaxation tests to determine the equilibrium tensile modulus of surface-zone cartilage. Water and glycosaminoglycan content were also measured at site-matched locations. The tensile moduli of the cartilage decreased significantly following meniscectomy. The linear region modulus decreased by 40%, from 25.5 +/- 7.7 to 15.3 +/- 7.2 MPa. There was a weak (r = -0.45), but significant, correlation between the linear region modulus and the gross morphological grade for cartilage damage. Water and glycosaminoglycan content did not change following meniscectomy. Composition was not correlated with mechanical properties or morphological grade, suggesting that cartilage structure may play a more important role than composition in determining the mechanical properties. The observed decrease in cartilage material properties provides a quantitative measure of the loss of cartilage function following meniscectomy and reflects a pattern of change that is consistent with damage to the collagen-proteoglycan solid network.
机译：半月板的丢失或损坏会改变膝关节的负荷方式，并经常导致软骨变性和骨关节炎。关节软骨的机械特性已显示出可反映人类骨关节炎和关节疾病实验模型中软骨退化的程度，但几乎没有实验数据可证明半月板切除术后软骨力学的变化。我们假设在全内半月板切除术后改变了关节软骨表面区域的拉伸特性。十二只杂种犬右膝内侧半月板接受了完全切除，并在术后12周研究了股骨软骨。我们进行了单轴拉伸应力松弛测试，以确定表面区域软骨的平衡拉伸模量。还在位点匹配的位置测量了水和糖胺聚糖的含量。半月板切除术后，软骨的拉伸模量显着降低。线性区域模量从25.5 +/- 7.7降低到15.3 +/- 7.2 MPa降低了40％。线性区域模量与软骨损伤的总体形态学等级之间存在弱相关性（r = -0.45），但具有显着相关性。半月板切除术后水和糖胺聚糖含量没有变化。成分与机械性能或形态学等级无关，表明软骨结构在确定机械性能方面可能比成分更重要。所观察到的软骨材料特性的下降提供了半月板切除术后软骨功能丧失的定量测量，并反映了与胶原蛋白多糖固体网络的破坏相一致的变化模式。

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