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首页> 外文期刊>Journal of orthopaedic research >Adhesion reduction after knee surgery in a rabbit model by Hyaloglide, a hyaluronan derivative gel.
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Adhesion reduction after knee surgery in a rabbit model by Hyaloglide, a hyaluronan derivative gel.

机译：透明质酸衍生物凝胶Hyaloglide在兔子模型中进行膝关节手术后减少粘连。

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A randomized controlled experimental trial was performed in a rabbit model of surgical adhesions to investigate the anti-adhesive effects of Hyaloglide, a highly viscous hyaluronan derivative absorbable gel after knee surgery. Twenty New Zealand white rabbits were prepared and randomly divided into two groups of 10 animals each. An intra-articular fibro-adhesive scar was created in the right knee joint of the hind paw of each rabbit using a standardized surgical procedure, and Hyaloglide was administered into the joint cavity of the knee at the end of intervention in the animals belonging to the treatment group. No anti-adhesive treatment was applied in the control group. Additionally, immobilization using a Kirschner wire was applied in order to increase the risk of adhesions. Six weeks after surgery the animals were euthanized and after removal of the immobilization system, adhesions were evaluated both macroscopically and histologically. Results of gross observations using a specific adhesion scoring system showed a significant reduction (p<0.01) of both incidence and severity of adhesions in the hyaluronan-treated group compared to the control group. Histologically, adhesions in the treated group were thinner with less collagenic fibers. In conclusion, Hyaloglide may be considered as a promising absorbable barrier for prevention of post-operative fibrotic adhesions after knee surgery.
机译：在兔手术粘连模型中进行了一项随机对照实验，以研究Hyaloglide（一种高粘度透明质酸衍生物可吸收凝胶，在膝盖手术后）的抗粘连作用。制备了20只新西兰白兔，并将其随机分为两组，每组10只动物。使用标准化手术方法在每只兔后爪的右膝关节中产生关节内纤维粘连性瘢痕，并在干预结束时将Hyaloglide施用至膝关节腔内，对属于这种动物的动物进行干预。治疗组。对照组未应用抗粘连治疗。另外，使用克氏针进行固定以增加粘连的风险。手术六周后，对动物实施安乐死，并移除固定系统后，从肉眼和组织学角度评估粘连。使用特定粘附力评分系统的总体观察结果显示，与对照组相比，透明质酸治疗组的粘附率和严重性均显着降低（p <0.01）。从组织学上看，治疗组的粘连较薄，胶原纤维较少。总之，Hyaloglide可以被认为是预防膝关节手术后纤维化粘连的有希望的可吸收屏障。

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