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首页> 外文期刊>Journal of orthopaedic research >Biomechanical evaluation of early fracture healing in normal and diabetic rats.
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Biomechanical evaluation of early fracture healing in normal and diabetic rats.

机译：正常和糖尿病大鼠早期骨折愈合的生物力学评估。

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摘要

Diabetes mellitus has been shown to alter the properties of bone and impair fracture healing in both humans and animals. The objective of this study was to document changes in the structural and material properties of intact bone and bone with healed fractures in diabetic rats compared with nondiabetic controls after 3 and 4 weeks of healing. Rods were inserted in the right femurs of control rats and rats with streptozotocin-induced diabetes, and the femurs were fractured in a standardized procedure and then allowed to heal for 3 and 4 weeks. After death, all femurs were mechanically tested to failure in torsion. The degree of healing was quantified for each animal by normalizing mechanical parameters for the femur with a healed fracture with those for the intact contralateral femur. At both time points of healing, diabetic rats exhibited inferior healing compared with that of control animals in terms of failure torque, failure stress, structural stiffness, and material stiffness of the femur with the healed fracture relative to the intact contralateral femur (p < 0.05). Our results demonstrate that the recovery of structural and material strength in femurs with healed fractures in diabetic rats is delayed by at least 1 week compared with that in controls.
机译：糖尿病已显示可改变人和动物的骨骼特性并损害骨折愈合。这项研究的目的是记录在愈合3周和4周后，与非糖尿病对照组相比，糖尿病大鼠完整的骨骼和骨折愈合的骨骼的结构和材料特性的变化。将杆插入对照大鼠的右股骨和链脲佐菌素诱发的糖尿病大鼠的股骨中，并以标准化的方法使股骨骨折，然后愈合3和4周。死亡后，对所有股骨进行机械测试以确认其扭转失败。通过使具有愈合的骨折的股骨的机械参数与完整的对侧股骨的机械参数标准化来量化每只动物的愈合程度。在愈合的两个时间点，相对于完整的对侧股骨，糖尿病大鼠在愈合扭矩的股骨的失败扭矩，失败应力，结构刚度和股骨材料刚度方面均比对照组动物差（p <0.05） ）。我们的结果表明，与正常对照组相比，糖尿病大鼠愈合骨折的股骨的结构和物质强度的恢复至少延迟了1周。

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