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首页> 外文期刊>Journal of orthopaedic research >Assessment of resorbable bioactive material for grafting of critical-size cancellous defects.
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Assessment of resorbable bioactive material for grafting of critical-size cancellous defects.

机译：评估可移植生物活性材料用于移植临界尺寸的松质骨缺损。

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Bioactive glasses form a surface apatite layer in vivo that enhances the formation and attachment of bone. Sol-gel Bioglass graft material provides greater nanoscale porosity than bioactive glass (on the order of 50-200 A), greater particle surface area, and improved resorbability, while maintaining bioactivity. This study histologically and biomechanically evaluated, in a rabbit model, bone formed within critical-sized distal femoral cancellous bone defects filled with 45S5 Bioglass particulates, 77S sol-gel Bioglass, or 58S sol-gel Bioglass and compared the bone in these defects with normal, intact, untreated cancellous bone and with unfilled defects at 4, 8, and 12 weeks. All grafted defects had more bone within the area than did unfilled controls (p < 0.05). The percentage of bone within the defect was significantly greater for the 45S5 material than for the 58S or 77S material at 4 and 8 weeks (p < 0.05), yet by 12 weeks equivalent amounts of bone were observed for all materials. By 12 weeks, all grafted defects were equivalent to the normal untreated bone. The resorption of 77S and 58S particles was significantly greater than that of 45S5 particles (p < 0.05). Mechanically, the grafted defects had compressive stiffness equivalent to that of normal bone at 4 and 8 weeks. At 12 weeks, 45S5-grafted defects had significantly greater stiffness (p < 0.05). At 8 and 12 weeks, all grafted defects had significantly greater stiffness than unfilled control defects (p < 0.05). In general, the 45S5-filled defects exhibited greater early bone ingrowth than did those filled with 58S or 77S. However, by 12 weeks, the bone ingrowth in each defect was equivalent to each other and to normal bone. The 58S and 77S materials resorbed faster than the 45S5 materials. Mechanically, the compressive characteristics of all grafted defects were equivalent or greater than those of normal bone at all time points.
机译：生物活性玻璃在体内形成表面磷灰石层，可增强骨骼的形成和附着。溶胶-凝胶生物玻璃接枝材料比生物活性玻璃（约50-200 A）具有更大的纳米级孔隙率，更大的颗粒表面积和更高的可吸收性，同时保持了生物活性。这项研究在兔子模型中进行了组织学和生物力学评估，确定了在临界尺寸的股骨远端松质骨缺损中形成的骨骼，其中充满了45S5 Bioglass微粒，77S sol-gel Bioglass或58S sol-gel Bioglass，并将这些缺损中的骨骼与正常骨骼进行了比较，完整，未经治疗的松质骨，以及在4、8和12周未填补的缺损。与未填充的对照相比，所有嫁接的缺损区域都有更多的骨头（p <0.05）。在第4周和第8周时，对于45S5材料，缺损内的骨百分比显着大于对58S或77S材料（p <0.05），但到12周时，所有材料的骨量均相等。到12周时，所有移植缺损均与正常未经治疗的骨等效。 77S和58S颗粒的吸收显着大于45S5颗粒（p <0.05）。机械上，移植后的缺损在4周和8周时的抗压刚度与正常骨的抗压刚度相当。在12周时，移植45S5的缺损具有明显更大的刚度（p <0.05）。在第8周和第12周，所有移植缺损的刚度均明显高于未填充的对照缺损（p <0.05）。通常，填充45S5的缺损比填充58S或77S的缺损具有更大的早期骨向内生长。但是，到12周时，每个缺损处的骨骼向内生长都彼此相等，并且与正常骨骼相等。 58S和77S材料比45S5材料吸收更快。在机械方面，所有移植缺损的压缩特性在所有时间点均与正常骨骼相同或更高。

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