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首页> 外文期刊>Journal of orthopaedic research >The effects of local and systemic alendronate delivery on wear debris-induced osteolysis in vivo.
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The effects of local and systemic alendronate delivery on wear debris-induced osteolysis in vivo.

机译：体内和局部阿仑膦酸盐递送对磨损碎片诱导的骨溶解的影响。

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摘要

We investigated the effects of locally and systemically administered alendronate on wear debris-induced osteolysis in vivo. Endotoxin-free titanium particles were injected into rabbit femurs, prior to insertion of a nonweight-bearing polymethylmethacrylate plug into the distal femur canal. Then the particles were repeatedly injected into the knee 2, 4, and 6 weeks after the implantation. Alendronate was incorporated at three different concentrations (0.1, 0.5, and 1.0 wt %) into bone cement for local delivery. For systemic delivery, alendronate was subcutaneously injected (1.0 mg/kg/week) 1 week after the implantation and then once a week until sacrifice. Eight weeks postoperatively, there was significant evidence of osteolysis surrounding the plug in the control group compared with markedly blocked osteolysis in the 0.5 wt % and the 1.0 wt % groups, and the systemic group. There was a concentration-dependent effect of alendronate-loaded bone cement on the improvement of peri-prosthetic bone stock. Notably, no significant differences were found between the 0.5 wt % and the systemic group in peri-prosthetic bone stock and implant fixation. Collectively, although the biological efficacy after the systemic delivery of alendronate was slightly higher than that in the local treatment groups, alendronate-loaded bone cement may be therapeutically effective in inhibiting titanium particle-induced osteolysis in vivo.
机译：我们调查了局部和全身给药的阿仑膦酸盐对体内磨损碎片诱导的骨溶解的影响。在将不承重的聚甲基丙烯酸甲酯塞子插入股骨远端管之前，将无内毒素的钛颗粒注入兔股骨。然后在植入后第2、4和6周将颗粒重复注射到膝盖中。将阿仑膦酸酯以三种不同浓度（0.1、0.5和1.0 wt％）掺入骨水泥中以进行局部递送。为了全身递送，在植入后1周皮下注射阿仑膦酸盐（1.0mg / kg /周），然后每周一次直至处死。术后八周，与0.5 wt％，1.0 wt％组和全身组明显的阻塞性骨溶解相比，对照组中有明显的溶栓现象。阿仑膦酸盐负载骨水泥对假体周围骨量的改善具有浓度依赖性。值得注意的是，在假体周围骨储备和植入物固定方面，0.5重量％和全身组之间没有发现显着差异。总体而言，尽管阿仑膦酸盐全身递送后的生物学功效略高于局部治疗组，但负载阿仑膦酸盐的骨水泥可能在体内抑制钛颗粒诱导的骨溶解方面具有治疗效果。

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