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首页> 外文期刊>Journal of orthopaedic research >Nucleus pulposus cells expressing hBMP7 can prevent the degeneration of allogenic IVD in a canine transplantation model
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Nucleus pulposus cells expressing hBMP7 can prevent the degeneration of allogenic IVD in a canine transplantation model

机译：表达hBMP7的髓核细胞可防止犬移植模型中同种异体IVD变性

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We have previously explored the possibilities of allogenic intervertebral disc (IVD) curing disc degeneration disease in clinical practice. The results showed that the motion and stability of the spinal unit was preserved after transplantation of allogenic IVD in human beings at 5-year follow-up. However, mild degeneration was observed in the allogenic transplanted IVD cases. In this study, we construct the biological tissue engineering IVD by injecting the nucleus pulposus cells (NPCs) expressing human bone morphogenetic protein 7 (hBMP7) into cryopreserved IVD, and transplant the biological tissue engineering IVD into a beagle dog to investigate whether NPCs expressing hBMP7 could prevent the degeneration of the transplanted allogenic IVDs. At 24 weeks after transplantation, MRI scan showed that IVD allografts injected NPCs expressing hBMP7 have a slighter signs of degeneration than IVD allografts with NPCs or without NPCs. The range of motion of left-right rotation in the group without NPCs was bigger than that of two cells injection group. PKH-26-labeled cells were identified at IVD allograft. The study demonstrated that NPCs expressing hBMP7 could survive at least 24 weeks and prevent the degeneration of the transplanted IVD. This solution might have a potential role in preventing the IVD allograft degeneration in long time follow-up.
机译：我们先前已经探索了在临床实践中同种异体椎间盘（IVD）治疗椎间盘退变疾病的可能性。结果表明，在同种异体IVD移植到人的5年随访中，保留了脊柱单元的运动和稳定性。然而，在同种异体移植IVD病例中观察到轻度变性。在这项研究中，我们通过将表达人骨形态发生蛋白7（hBMP7）的髓核细胞（NPC）注入冷冻保存的IVD中来构建生物组织工程IVD，并将该生物组织工程IVD移植到比格犬中以研究是否表达hBMP7的NPC可以防止移植的异体IVD变性。移植后第24周，MRI扫描显示，用IVD同种异体移植物注射表达hBMP7的NPC与有NPC或无NPC的IVD同种异体移植相比，具有较轻的变性迹象。没有鼻咽癌的组的左右旋转运动范围大于两个细胞注射组。在IVD同种异体移植中鉴定了PKH-26标记的细胞。该研究表明，表达hBMP7的NPC可以存活至少24周，并且可以防止移植的IVD的变性。在长时间的随访中，该解决方案可能具有防止IVD同种异体移植变性的潜在作用。

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