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首页> 外文期刊>Journal of orthopaedic research >Positive effect of IGF-1 injection on gastrocnemius of rat during distraction osteogenesis
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Positive effect of IGF-1 injection on gastrocnemius of rat during distraction osteogenesis

机译：IGF-1注射对成骨过程中大鼠腓肠肌的正作用

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Distraction osteogenesis (DO) is used to form new bone between bone segments to lengthen the callus. Skeletal muscles frequently fail to adapt to distraction, which causes complications. Insulin-like growth factor-1 (IGF-1) has been implicated as a central regulator of muscle repair. We hypothesized that IGF-1 injection could reduce muscle complications in DO. A total of 102 Sprague-Dawley rats received DO or did not were randomly assigned into saline, IGF-1 and normal groups. On the day before the distraction, the rats in the IGF-1 group were injected with IGF-1. The gastrocnemius muscles of the rats were harvested at the 0, 1st, 4th, 7th, and 10th days of distraction. The weight of the muscles, cross-sectional area (CSA) of the muscle fibers, collagen volume fraction (CVF), maximum limit load (MLL), maximum contraction forces, and gene expression of Akt, MyoD, myogenin, myostatin, and collagen I were analyzed. The results indicated that IGF-1 injection had increased the weights, CSA of the muscle fibers, MLL and force generation of the gastrocnemius. Also, Akt, MyoD, and myogenin were upregulated, and myostatin was downregulated in the IGF-1 group. Injection of IGF-1 could attenuate the gastrocnemius atrophy, prevent fibrosis, increase MLL, and regulate the related mRNA. (c) 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:1424-1432, 2015.
机译：分心成骨术（DO）用于在各骨段之间形成新骨，以延长愈伤组织。骨骼肌经常无法适应分散注意力，这会引起并发症。胰岛素样生长因子-1（IGF-1）被认为是肌肉修复的中央调节剂。我们假设注射IGF-1可以减少DO中的肌肉并发症。共有102只Sprague-Dawley大鼠接受DO或未随机分为盐水，IGF-1和正常组。在分心前一天，向IGF-1组的大鼠注射IGF-1。在分心的第0、1、4、7和10天收获大鼠腓肠肌。肌肉重量，肌肉纤维横截面积（CSA），胶原蛋白体积分数（CVF），最大极限负荷（MLL），最大收缩力以及Akt，MyoD，肌生成素，肌生长抑制素和胶原蛋白的基因表达我被分析了。结果表明，IGF-1注射增加了体重，肌纤维的CSA，MLL和腓肠肌的力量生成。另外，IGF-1组的Akt，MyoD和肌生成素被上调，而肌生长抑制素被下调。注射IGF-1可减轻腓肠肌萎缩，预防纤维化，增加MLL并调节相关mRNA。 （c）2015骨科研究学会。由Wiley Periodicals，Inc.出版，J Orthop Res 33：1424-1432，2015。

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