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首页> 外文期刊>Journal of oral pathology and medicine: Official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology >Secondary jaw aneurysmal bone cyst (JABC) - a possible misnomer? A review of literature on secondary JABCs, their pathogenesis and oncogenesis
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Secondary jaw aneurysmal bone cyst (JABC) - a possible misnomer? A review of literature on secondary JABCs, their pathogenesis and oncogenesis

机译：继发性颌下动脉瘤性骨囊肿（JABC）-可能的误称？关于继发性JABCs，其发病机制和致癌作用的文献综述

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Context: Aneurysmal bone cysts are rare pseudocysts, commonly seen in long bones and vertebral column. Although a well described and reported lesion, many misconceptions still prevail regarding their etiopathogenesis. Many of the reported cases of jaw aneurysmal bone cysts (JABC) present with another bone pathology. Aims: The purpose of this review was to evaluate the incidence of neoplastic lesions occurring simultaneously with a JABC (in contrast to primary JABCs). Any pathogenetic and oncogenetic association between primary and secondary jaw ABCs has been reviewed and discussed. Settings and Design: A methodical narrative review of literature was performed, given the incidence of mostly case reports on this topic. Methods and Material: A methodical electronic search of Pubmed, Pubmed Central, Medline and Cochrane databases was performed for reported cases of JABC. These articles were analysed and segregated into primary and secondary ABC and, if secondary, the lesion it concurrently occurred with. Another search was conducted to yield articles discussing the cytopathogenetic and oncogenetic origins of ABCs. Results and Conclusions: About 15% of the ABCs reported were of secondary nature. Amongst the associated lesions, cement-ossifying fibroma and ossifying fibroma were the most common, followed by fibrous dysplasia and central giant cell granuloma. No ABCs were associated with metastatic changes. The search for histopathogenesis pointed to a specific cytogenetic abnormality as the origin of primary ABCs, with USP6 as its main oncogene and spindle cell as the neoplastic cell, unlike with secondary ABCs, suggesting that they are distinct pathological processes.
机译：背景：动脉瘤性骨囊肿是罕见的假性囊肿，常见于长骨和椎骨柱中。尽管已充分描述并报告了病变，但许多有关其病因的误解仍普遍存在。报道的许多颌骨动脉瘤性骨囊肿（JABC）病例都具有另一种骨病理学。目的：本综述旨在评估与JABC同时发生的肿瘤性病变的发生率（与原发性JABC相反）。初级和次级颌骨ABC之间的任何致病和致癌关联均已进行了审查和讨论。设置与设计：鉴于有关该主题的大多数病例报告的发生，对文献进行了系统的叙述性回顾。方法和材料：对报道的JABC病例进行有条不紊的电子搜索，包括Pubmed，Pubmed Central，Medline和Cochrane数据库。对这些文章进行了分析，并将其分为原发性和继发性ABC，如果是继发性则与之同时发生。进行了另一次搜索以产生讨论ABC的细胞致病和致癌起源的文章。结果与结论：报告的ABC中约有15％是次生的。在相关的病变中，骨水泥性纤维化瘤和骨化性纤维瘤最常见，其次是纤维异常增生和中央巨细胞肉芽肿。没有ABC与转移性变化相关。对组织病理学的研究指出，特定的细胞遗传学异常是原发性ABCs的起源，与继发性ABCs不同，USP6是其主要致癌基因，纺锤形细胞是瘤性细胞，表明它们是不同的病理过程。

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