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首页> 外文期刊>Journal of pediatric and adolescent gynecology >Normal ovarian structure and function with normal glucose tolerance in girls with early treatment of classic congenital adrenal hyperplasia.
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Normal ovarian structure and function with normal glucose tolerance in girls with early treatment of classic congenital adrenal hyperplasia.

机译：早期治疗经典先天性肾上腺增生的女孩卵巢结构和功能正常，糖耐量正常。

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Hyperandrogenism and hyperinsulinism have both been suggested as etiologic factors behind functional ovarian hyperandrogenism or polycystic ovary syndrome. Females with congenital adrenal hyperplasia provide a clinical model to evaluate the contribution of pre- and post-natal hyperandrogenism on ovarian structure and function. STUDY OBJECTIVE: To evaluate glucose tolerance, and structure and androgen production of the ovaries in young females with classic congenital adrenal hyperplasia. DESIGN, SETTING, PARTICIPANTS: Cross-sectional study, including the enrollment of participants, ages 8 to 20 years, recruited from the pediatric endocrinology clinical program of a tertiary pediatric referral center. INTERVENTIONS: Ten participants had oral glucose tolerance testing, adrenal and ovarian androgen measurements, and pelvic ultrasound studies performed. MAIN OUTCOME MEASURES: Presence of altered response to glucose challenge, ovarian hyperandrogenism, or presence of polycystic ovaries by ultrasound. RESULTS: Measurements of fasting blood glucose, post-challenge glucose, and insulin resistance were normal in this sample. There was no evidence of ovarian hyperandrogenism after adrenal suppression with dexamethasone. All participants had normal ovarian structure without evidence of polycystic ovaries. CONCLUSIONS: Females with classic congenital adrenal hyperplasia (21-hydroxylase deficiency) and normal glucose tolerance appear to have normal ovarian structure and function during the peripubertal period.
机译：高雄激素血症和高胰岛素血症均已被认为是功能性卵巢高雄激素血症或多囊卵巢综合征的病因。先天性肾上腺增生的女性提供了一种临床模型，以评估产前和产后高雄激素血症对卵巢结构和功能的贡献。研究目的：评估经典先天性肾上腺皮质增生的年轻女性的葡萄糖耐量，卵巢的结构和雄激素产生。设计，地点，参与者：横断面研究，包括从三级儿科转诊中心的儿科内分泌临床计划招募的8至20岁的参与者。干预措施：十名参与者进行了口服葡萄糖耐量测试，肾上腺和卵巢雄激素测量以及盆腔超声检查。主要观察指标：超声检查对葡萄糖刺激，卵巢高雄激素血症或多囊卵巢的反应有所改变。结果：空腹血糖，攻击后血糖和胰岛素抵抗的测量正常。没有证据表明地塞米松抑制肾上腺后会引起卵巢高雄激素血症。所有参与者的卵巢结构正常，没有多囊卵巢的迹象。结论：患有典型的先天性肾上腺皮质增生（21-羟化酶缺乏症）和葡萄糖耐量正常的女性在青春期前似乎具有正常的卵巢结构和功能。

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