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首页> 外文期刊>Journal of pediatric endocrinology & metabolism: JPEM >Short stature, celiac disease and growth hormone deficiency.
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Short stature, celiac disease and growth hormone deficiency.

机译：身材矮小，腹腔疾病和生长激素缺乏症。

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摘要

Celiac disease (CD) is a prevalent, genetically determined, autoimmune, chronic inflammatory state caused by intolerance to gluten that results mainly in gastrointestinal manifestations. One of the most common extra-intestinal manifestations of CD is short stature, and in some patients, short stature may be the presenting and only symptom of the disease, making the diagnosis of CD challenging. Impaired growth in children with CD results mainly from nutritional deficits, and withdrawal of gluten from the diet is frequently associated with a marked improvement of linear growth. In some patients, CD may be characterized by growth hormone (GH) resistance, as suggested by normal or elevated GH levels and low insulin-like growth factor-I (IGF-I) levels. Rarely, it has been shown that poor catch-up growth and/or IGF-I response to gluten-free diet may be due to the coexistence of celiac disease and GH deficiency. We present two children with coexisting CD and GH deficiency. One patient had MRI findings suggesting congenital isolated GH deficiency, and a possibility of developing multiple pituitary hormone deficiencies later in life.
机译：乳糜泻（CD）是一种普遍的，由基因决定的，自身免疫性的，慢性炎症性疾病，由对面筋的不耐受引起，主要导致胃肠道表现。 CD的最常见的肠道外表现之一是矮小，在某些患者中，矮小可能是疾病的表现，并且只是该病的症状，这使得CD的诊断具有挑战性。患有CD的儿童的生长障碍主要是由于营养不足造成的，从饮食中提取面筋通常与线性生长显着改善有关。在某些患者中，CD的特征可能在于生长激素（GH）抵抗力，如正常或升高的GH水平和低的胰岛素样生长因子I（IGF-1）水平所暗示的。很少有研究表明，对无麸质饮食的追赶生长和/或IGF-I反应差可能是由于乳糜泻和GH缺乏症并存。我们介绍了两个患有CD和GH缺乏症的儿童。一名患者的MRI表现提示先天性孤立性GH缺乏，并可能在以后的生活中发展出多种垂体激素缺乏。

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