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首页> 外文期刊>Journal of pediatric endocrinology & metabolism: JPEM >Accelerated early pubertal progression, ovarian morphology, and ovarian function in prospectively followed low birth weight (LBW) girls.
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Accelerated early pubertal progression, ovarian morphology, and ovarian function in prospectively followed low birth weight (LBW) girls.

机译：低出生体重（LBW）女孩的预期青春期早期进展，卵巢形态和卵巢功能加速。

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摘要

Abstract Aim: To compare pubertal development in age-matched healthy girls born with low birth weight (LBW) or appropriate birth weight for gestational age (AGA). Subjects and methods: Girls with breast in Tanner stage II and normal body mass index were followed for 3 years with a complete physical exam, bone age, pelvic ultrasound, and measurement of gonadal hormones using a leuprolide test. Results: Forty-one girls (AGA 25/LBW 16) were followed up for 3 years. By 3 years, they had similar bone age, adjusted height, and body composition. In LBW girls, breast Tanner stage advanced faster during the first 2 years of follow-up, which was associated with higher serum androgens. Hirsutism score, ovarian volume, and number of follicles between AGA and LBW were not different nor was age of menarche. By the third year, basal and poststimulated levels of gonadotropins and androgens anti-Müllerian hormone and inhibin B were similar in both groups and did not show differences related to birth weight or degree of catch-up growth. Conclusion: LBW recruits showed a slightly faster breast development but no differences in androgen excess signs, internal genitalia, and gonadal hormonal patterns.
机译：摘要目的：比较年龄低，体重低（LBW）或适合胎龄的体重（AGA）的年龄匹配的健康女孩的青春期发育。受试者和方法：随访3年的Tanner II期乳房和正常体重指数正常的女孩，进行全面的体格检查，骨龄，骨盆超声检查，并使用亮丙瑞林试验测量性腺激素。结果：对41名女孩（AGA 25 / LBW 16）进行了3年的随访。到3年时，他们的骨龄，调整的身高和身体组成都差不多。在LBW女孩中，在随访的前2年中，乳房Tanner期的进展更快，这与较高的血清雄激素有关。 AGA和LBW之间的组织分裂评分，卵巢容量和卵泡数量无差异，初潮年龄也无差异。到第三年，两组的基础水平和刺激后水平的促性腺激素和雄激素抗苗勒管激素和抑制素B相似，并且没有显示出与出生体重或追赶成长程度有关的差异。结论：LBW新兵的乳房发育略快，但雄激素过多体征，内部生殖器和性腺激素模式无差异。

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