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首页> 外文期刊>Journal of pediatric endocrinology & metabolism: JPEM >Hashimoto's encephalopathy: a rare pediatric brain disease
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Hashimoto's encephalopathy: a rare pediatric brain disease

机译：桥本脑病：一种罕见的小儿脑病

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We report a 9-year-old female who presented with new onset intractable seizure activity followed by a prolonged encephalopathic state. After ruling out common etiologies, Hashimoto's encephalopathy (HE) was considered, and antibody levels to thyroid peroxidase and thyroglobulin were both markedly elevated in her serum. She was euthyroid at the time of presentation. Upon treatment with high dose methylprednisolone, the patient demonstrated a significant improvement in her encephalopathy. The diagnosis of HE requires strong clinical suspicion with evidence of antithyroid antibodies, as well as an encephalopathy not explained by another etiology. While well documented in the adult literature, only a handful of pediatric cases have been described to date. Patients with HE have a nearly universal response to high dose glucocorticoids. HE should be considered in the differential diagnosis of any patient, adult or pediatric, who displays prolonged, unexplainable encephalopathy.
机译：我们报告了一名9岁的女性，该女性呈现出新的发作性顽固性癫痫发作活动，随后出现长时间的脑病状态。排除常见病因后，考虑桥本脑病（HE），并且其血清中针对甲状腺过氧化物酶和甲状腺球蛋白的抗体水平均显着升高。出诊时她甲状腺功能正常。经大剂量甲基强的松龙治疗后，患者脑病得到了明显改善。 HE的诊断需要强烈的临床怀疑，要有抗甲状腺抗体的证据，以及其他病因无法解释的脑病。尽管在成人文献中有充分的文献记载，但迄今为止仅描述了少数儿科病例。 HE患者对大剂量糖皮质激素的反应几乎普遍。在表现出长期，无法解释的脑病的任何成人或儿童患者的鉴别诊断中均应考虑HE。

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