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首页> 外文期刊>Journal of pediatric gastroenterology and nutrition >Serum soluble interleukin-2 receptor, interleukin-6, and tumor necrosis factor-alpha levels in children with celiac disease: response to treatment.
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Serum soluble interleukin-2 receptor, interleukin-6, and tumor necrosis factor-alpha levels in children with celiac disease: response to treatment.

机译：乳糜泻患儿的血清可溶性白细胞介素2受体，白细胞介素6和肿瘤坏死因子-α水平：对治疗的反应。

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OBJECTIVES: T-cell mediated immune response to dietary gluten and cytokines release are important for the enteropathy seen in celiac disease. We investigated the serum levels of soluble interleukin-2 receptor, interleukin-6, and tumor necrosis factor-alpha in celiac children before and after gluten exclusion. METHODS: Cytokine levels were determined using enzyme immunoassay in serum from 12 untreated celiac patients, 16 treated celiac patients on a gluten-free diet for at least two years, and from 26 control children. Eight of 12 untreated patients were also investigated at 6 and 12 months after gluten exclusion. Serum IgA antiendomysium antibodies were also assayed by indirect immunofluorescence. RESULTS: Soluble interleukin-2 receptor and interleukin-6 levels were significantly increased in untreated celiac patients compared with treated and control children. There was no difference in the tumor necrosis factor-alpha levels between the groups. Soluble interleukin-2 receptor levels were the only ones significantly decreased at 12 months after gluten exclusion. However, soluble interleukin-2 receptor and interleukin-6 levels at 12 months were significantly higher compared with controls. Antiendomysium antibodies had a diagnostic sensitivity of 100% and the titers decreased significantly after 12 months of gluten exclusion. A significant positive correlation was found between antiendomysium antibody titers with both soluble interleukin-2 receptor and interleukin-6 values. CONCLUSIONS: The serum soluble interleukin-2 receptor and interleukin-6 levels may be used as a noninvasive measure of celiac disease activity and response to treatment.
机译：目的：T细胞介导的对饮食面筋和细胞因子释放的免疫反应对于乳糜泻所见的肠病很重要。我们调查了排除麸质前后儿童腹腔儿童可溶性白细胞介素2受体，白细胞介素6和肿瘤坏死因子-α的血清水平。方法：采用酶联免疫法测定了12名未经治疗的乳糜泻患者，16名接受无麸质饮食至少两年的治疗的乳糜泻患者以及26名对照儿童血清中的细胞因子水平。在排除麸质后的第6和12个月，还调查了12名未经治疗的患者中的8名。还通过间接免疫荧光测定了血清IgA抗内胚层抗体。结果：与治疗和对照儿童相比，未经治疗的腹腔疾病患者可溶性白细胞介素2受体和白细胞介素6水平显着增加。两组之间的肿瘤坏死因子-α水平无差异。排除麸质后12个月，可溶性白细胞介素2受体水平是唯一显着下降的水平。但是，与对照组相比，在12个月时可溶性白细胞介素2受体和白细胞介素6的水平明显更高。抗内胚层抗体的诊断敏感性为100％，排除麸质12个月后滴度显着降低。发现抗内膜抗体滴度与可溶性白细胞介素2受体和白细胞介素6值之间存在显着正相关。结论：血清可溶性白细胞介素2受体和白细胞介素6水平可作为乳糜泻活性和对治疗反应的一种非侵入性测量方法。

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