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Genetics and non-syndromic facial growth

机译：遗传和非综合征性面部生长

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Just as pediatricians and endocrinologists are interested in understanding statural growth patterns and the prediction of adult height, pediatric dentists, orthodontists, and oral/maxillofacial surgeons need to be knowledgeable about a patient's facial growth patterns to effectively treat them. Some variations in facial growth have been clinically associated with a poor esthetic self-image, malocclusion formation and the development of physical and/or functional deformity. To understand how different genetic factors influence growth and development patterns, scientists and clinicians study developmental sequences, malformations and syndromes. While understanding this general information can be clinically valuable when making treatment decisions for an individual and their family, the greatest contribution of genetics in clinical practice may be in the form of personalized or "precision" medicine in the general population. Precision medicine takes into account knowing a portion or all of a patient's specific DNA code to estimate how their genetic makeup will influence growth and development patterns. Ultimately, the identification of key genetic variations at the level of the individual patient can improve growth predictions for that patient and may be indicative of how well they will respond to specific forms of treatment.
机译：就像儿科医生和内分泌学家对了解统计学上的生长方式以及对成人身高的预测感兴趣一样，儿科牙医，正畸医生和口腔/颌面外科医师也需要了解患者的面部生长方式，才能有效地对其进行治疗。面部生长的某些变化在临床上与不良的审美自我形象，错牙合畸形以及身体和/或功能畸形的发展有关。为了了解不同的遗传因素如何影响生长和发育模式，科学家和临床医生研究了发育序列，畸形和综合症。尽管了解此一般信息在为个人及其家庭做出治疗决策时具有临床价值，但遗传学在临床实践中的最大贡献可能是以普通人群中个性化或“精确”医学的形式出现的。精密医学考虑到知道患者的部分或全部特定DNA编码，以估计其遗传构成将如何影响生长发育模式。最终，在单个患者水平上鉴定关键遗传变异可以改善对该患者的生长预测，并且可以指示他们对特定治疗方式的反应程度。

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