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首页> 外文期刊>Journal of pediatric genetics >Newborn measles antibody profile in a teaching hospital: Can sex of babies determine measles IgG acquisition from their respective mothers?
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Newborn measles antibody profile in a teaching hospital: Can sex of babies determine measles IgG acquisition from their respective mothers?

机译：一家教学医院的新生儿麻疹抗体谱：婴儿的性别可以决定从其各自母亲那里获得的麻疹IgG吗？

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摘要

Known sex specific differences in fetal, neonatal morbidity and mortality have been documented. Sex differences also exist in birth-weight centile with males being larger than females at birth. However, these sex differences are not fully explored when studying passive measles immunity acquired by babies from their mothers. Moreover, the mechanisms that confer these sex differences are to a large extent unknown. Therefore, this study assessed sex of babies as a determinant of measles immu-noglobulin G acquisition from their respective mothers. One hundred and seventy four newborn babies were enrolled in this study. Enzyme linked immunosorbent assay was used to measure maternal measles antibodies (MMA) from sera collected from these babies at birth. Gestational age of the newborn babies was determined using the Nagele rule, ultrasound scan reports and the Dubowitz criteria. Sex and mean MMA of these babies was compared using the Student's t test. Significant comparison existed between mean MMA and sex of post term babies (P = 0.000), such that post term males had higher levels of MMA than females. However, overall sex and mean MMA comparison of these babies was not significant (P = 0.977). There were more MMA in male post term babies relative to their female peers; however, overall sex comparison of MMA was not significant. Therefore, there is the need for further study.
机译：胎儿，新生儿发病率和死亡率方面已知的性别差异已被记录。出生体重体重百分位数也存在性别差异，男性出生时大于女性。但是，在研究婴儿从母亲那里获得的被动麻疹免疫力时，尚未充分探讨这些性别差异。而且，在很大程度上，导致这些性别差异的机制尚不清楚。因此，本研究评估了婴儿的性别是从其各自母亲那里获得麻疹免疫球蛋白G的决定因素。这项研究招募了174名新生婴儿。酶联免疫吸附测定法用于测量从这些婴儿出生时收集的血清中的母体麻疹抗体（MMA）。新生儿的胎龄由Nagele规则，超声扫描报告和Dubowitz标准确定。使用Student's t检验比较了这些婴儿的性别和平均MMA。在平均MMA和足月婴儿性别之间存在显着比较（P = 0.000），因此足月男性的MMA水平高于女性。但是，这些婴儿的总体性别和平均MMA比较无统计学意义（P = 0.977）。相对于女性同龄人，男性足月儿中的MMA更多。但是，MMA的总体性别比较并不显着。因此，有必要进一步研究。

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