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首页> 外文期刊>Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis >Quality evaluation of commercial Huang-Lian-Jie-Du-Tang based on simultaneous determination of fourteen major chemical constituents using high performance liquid chromatography
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Quality evaluation of commercial Huang-Lian-Jie-Du-Tang based on simultaneous determination of fourteen major chemical constituents using high performance liquid chromatography

机译：基于高效液相色谱法同时测定14种主要化学成分的商业黄连街杜塘质量评估

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摘要

Huang-Lian-Jie-Du-Tang (HLJDT), comprising Coptidis Rhizoma, Scutellariae Radix, Phellodendri Cortex and Gardeniae Fructus, is one of the commonly used Chinese medicine formulas for clearing heat and detoxifying. Quality control of the herbal complex like Chinese medicine formulas still remains a challenge. The successful approval of botanical drug Veregen by FDA indicated the importance of quantitative analysis in quality control of herbal medicines. In this study, an effective quantitative method based on conventional HPLC-DAD was developed for simultaneous determination of fourteen major ingredients (seven alkaloids, four flavonoids, three terpenes) in HLJDT. The established method was well validated in terms of linearity, sensitivity, precision, accuracy and stability and then successfully applied to quality evaluation of commercial HLJDT samples. The developed method can quantitatively determine up to 70% of the chemicals of commercial HLJDT sample and effectively revealed the significant variation in the quality of the commercial HLJDT samples collected from different locations.
机译：黄连解毒汤（HLJDT）是黄连解毒的常用中药配方之一，由黄连，黄S，黄柏和Garden子组成。中草药配方等草药复合物的质量控制仍然是一个挑战。 FDA对植物药Veregen的成功批准表明了定量分析在草药质量控制中的重要性。在这项研究中，开发了一种基于常规HPLC-DAD的有效定量方法，用于同时测定HLJDT中的14种主要成分（七个生物碱，四个类黄酮，三个萜烯）。所建立的方法在线性，灵敏度，精密度，准确性和稳定性方面得到了充分验证，然后成功地应用于商业HLJDT样品的质量评估。所开发的方法可以定量测定多达70％的商业HLJDT样品中的化学物质，并有效地揭示了从不同位置收集的商业HLJDT样品的质量存在显着差异。

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