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Historical review of melanoma treatment and outcomes

机译:黑色素瘤治疗和结果的历史回顾

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The surgical and medical management of melanoma has changed dramatically since the first description of melanoma as a disease entity more than 200 years ago. Refinement of surgical techniques, including evaluation of optimal surgical margins, utility of elective lymph node dissection, and incorporation of sentinel lymph node mapping as both a prognostic tool and guide for selective lymphadenectomy have lessened surgical morbidity and improved outcomes for early-stage and locally advanced melanoma. Astute clinical observations of the integrated roles of the immune system and oncogenic mutations have more recently led to improvements in survival and quality of life for advanced melanoma. Herein, we provide an overview of the most significant surgical and medical milestones in the treatment of melanoma over the past 2 centuries. ? 2013 Elsevier Inc.
机译:自从200多年前首次将黑色素瘤描述为疾病实体以来,黑色素瘤的外科和医学管理发生了巨大变化。完善的手术技术,包括评估最佳手术切缘,选择性淋巴结清扫术的实用性以及将前哨淋巴结作图结合作为选择性淋巴结清扫术的预后工具和指南,均降低了手术发病率,并改善了早期和局部晚期的预后黑色素瘤。对免疫系统和致癌突变的整合作用的敏锐临床观察最近导致晚期黑素瘤的生存率和生活质量得到改善。在此,我们概述了过去两个世纪以来黑色素瘤治疗中最重要的外科和医学里程碑。 ? 2013爱思唯尔公司

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