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首页> 外文期刊>Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis >The development and validation of a rapid method for the determination of antimicrobial agent residues in milk and meat using ultra performance liquid chromatography coupled to quadrupole - Orbitrap mass spectrometry
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The development and validation of a rapid method for the determination of antimicrobial agent residues in milk and meat using ultra performance liquid chromatography coupled to quadrupole - Orbitrap mass spectrometry

机译：高效液相色谱-四极杆-Orbitrap质谱联用快速测定牛奶和肉中抗菌剂残留量的方法的建立和验证。

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摘要

A new multi-class method has been developed for the identification and quantification of the residues of 26 antibiotics from different classes (sulfonamides, macrolides, tetracyclines, penicillins, and quinolones) in milk and meat by ultra performance liquid chromatography coupled to hybrid quadrupole - high resolution Orbitrap mass spectrometry (UPLC-qOrbitrap). The sample preparation included extraction of two analytical portions with acetonitrile and 5% trichloroacetic acid, respectively, followed by centrifugation and filtration. The method was validated over three days at 50% of MRL (maximum residue limit) set in the European Union. Experiments on spiked meat and milk samples showed that the average recovery of the antibiotics ranged from 83% to 112%, and the coefficients of variation were between 8.9% and 39%. (C) 2014 Elsevier B.V. All rights reserved.
机译：已开发出一种新的多类方法，通过超高效液相色谱-混合四极杆-高分离度鉴定和定量测定牛奶和肉类中26种不同类别（磺酰胺，大环内酯，四环素，青霉素和喹诺酮）抗生素的残留量分辨率Orbitrap质谱（UPLC-qOrbitrap）。样品制备包括分别用乙腈和5％三氯乙酸萃取两个分析部分，然后进行离心和过滤。该方法在欧盟设定的最大残留限量（MRL）的50％的情况下经过三天的验证。对加标的肉类和奶类样品进行的实验表明，抗生素的平均回收率在83％至112％之间，变异系数在8.9％至39％之间。 （C）2014 Elsevier B.V.保留所有权利。

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