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首页> 外文期刊>Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis >Evaluation of the performance of commercially available polysaccharide-based chiral stationary phases after multicycle operation in multimodal elution mode.
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Evaluation of the performance of commercially available polysaccharide-based chiral stationary phases after multicycle operation in multimodal elution mode.

机译：在多峰洗脱模式下进行多循环操作后，评估市售的基于多糖的手性固定相的性能。

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摘要

The performance of four commercially available polysaccharide-based chiral stationary phases, Chiralcel OD, Chiralcel OJ, Chiralpak AD and Chiralpak AS was evaluated after several cycles of extended multimodal operations. Acetonitrile, methanol, ethanol and their mixtures were chosen for polar-organic mobile phases, ethanol-n-heptane mixture and n-heptane were selected for normal-phase mode. Retention factor (k), selectivity (alpha), resolution (Rs) and theoretical plate count (N) were the chosen parameters to describe the column performance. One racemate for which all four columns have shown enantioselectivity was chosen as test compound. After 15 cycles of multimodal operations a slight decrease was seen in the retention factors (k) however, column efficiency, selectivity (alpha) and resolution (Rs) were maintained.
机译：经过数个扩展的多峰操作循环后，评估了四种可商购的基于多糖的手性固定相Chiralcel OD，Chiralcel OJ，Chiralpak AD和Chiralpak AS的性能。极性有机流动相选择乙腈，甲醇，乙醇及其混合物，正相模式选择乙醇-正庚烷混合物和正庚烷。保留因子（k），选择性（alpha），分离度（Rs）和理论塔板数（N）是描述色谱柱性能的选定参数。选择所有四个色谱柱均显示对映选择性的外消旋体作为测试化合物。经过15个多峰操作循环后，保留因子（k）略有下降，但是，柱效，选择性（alpha）和分离度（Rs）得以保持。

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