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首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >PHOTOPIGMENTS AND CIRCADIAN SYSTEMS OF VERTEBRATES
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PHOTOPIGMENTS AND CIRCADIAN SYSTEMS OF VERTEBRATES

机译：脊椎的光色素和锡德系

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In the retinal degeneration (rd) mouse the absence of rod cells and the progressive loss of cones does not result in a decrease in circadian phase shifting responses to light. By contrast, rd/rd mice are unable to perform simple visual tasks. In addition, rodless transgenic mice, and mice homozygous for the retinal degeneration slow (rds) mutation, show unattenuated circadian responses to light. Collectively these data suggest that cone cells lacking outer segments are sufficient to maintain normal circadian responses to light, or some unidentified photoreceptor within the retina. An action spectrum for circadian responses to light in rd/rd mice, and molecular analysis of retinally degenerate mice and blind mole rat eyes, suggests the involvement of a mid-to-long wavelength sensitive cone opsin in photoentrainment. Extraocular photoreceptors of non-mammalian vertebrates are currently being analyzed in order to identify functional and evolutionary similarities between visual and non-visual photoreceptor systems. [References: 39]
机译：在视网膜变性（rd）小鼠中，杆状细胞的缺乏和视锥细胞的逐渐丧失不会导致昼夜节律对光的响应降低。相反，rd / rd鼠标无法执行简单的视觉任务。此外，无杆转基因小鼠和视网膜变性慢（rds）突变纯合的小鼠显示昼夜节律对光的反应。总的来说，这些数据表明，缺乏外部节段的视锥细胞足以维持对光或视网膜内某些未识别的感光体的正常生理反应。昼夜节律对rd / rd小鼠的光反应的作用谱，以及视网膜变性小鼠和盲痣鼠眼的分子分析表明，中长波长敏感视锥蛋白参与了光夹带。目前正在对非哺乳动物脊椎动物的眼外感光体进行分析，以鉴定视觉和非视觉感光体系统之间的功能和进化相似性。 [参考：39]

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