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首页> 外文期刊>Journal of pharmaceutical sciences. >Polymorphism on leflunomide: stability and crystal structures.
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Polymorphism on leflunomide: stability and crystal structures.

机译：来氟米特的多态性：稳定性和晶体结构。

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摘要

Two polymorphs of Leflunomide were found and studied (form I and II). Both of them were characterized by X-ray powder diffraction and thermal analysis. Single crystals were obtained and both structures were solved. Forms I and II crystallize in the space group P2(1)/c with two and one independent molecules per asymmetric unit, respectively. Thermodynamic stability of the two forms is assessed by differential scanning calorimetry. The cohesion in the crystal of form I (the more stable) is provided by both by H bonding as well as pi...pi interactions, while in form II it is given only by the former. The independent molecules in form I adopt different conformations thus allowing for a larger number of intermolecular interactions.
机译：发现并研究了来氟米特的两种多晶型物（形式I和II）。它们都通过X射线粉末衍射和热分析来表征。获得了单晶并解析了两种结构。形式I和II在空间组P2（1）/ c中每个不对称单元分别具有两个和一个独立的分子结晶。通过差示扫描量热法评估两种形式的热力学稳定性。晶型I（更稳定）的晶体内聚力是通过H键以及pi ... pi相互作用提供的，而晶型II中的内聚力仅由前者提供。形式I的独立分子采用不同的构象，因此允许大量的分子间相互作用。

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