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首页> 外文期刊>Journal of pharmaceutical sciences. >Importance of divalent cations in nanolipoplex gene delivery.
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Importance of divalent cations in nanolipoplex gene delivery.

机译：二价阳离子在纳米脂质复合物基因递送中的重要性。

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Gene therapy is a promising therapeutic strategy to combat genetic or acquired diseases at their root cause rather than just treating symptoms. It is well recognised that there is an urgent need for non-toxic and efficient gene delivery vectors to fully exploit the current potential of gene therapy in molecular medicine. Cell-specific targeting of bioactive nucleotides is a prerequisite to attain the concentration of nucleic acids required for therapeutic efficacy in the target tissue. Many metal ions such as Mg2+, Mn2+, Ba2+ and, most importantly, Ca2+ have been demonstrated to have significant roles in gene delivery. These inorganic cations show low toxicity, good biocompatibility and promise for controlled delivery properties, thus presenting a new alternative to toxic and immunogenic carriers. Recently, inorganic nanoparticles alone, or in combination with a colloidal particulate system such as nanoliposome, an advanced approach to gene delivery, were found to exert a positive effect on gene transfer. In this report, the role of the divalent cations in nucleic acid delivery, particularly with respect to the potential improvement of transfection efficiency of nanolipoplexes, is reviewed.
机译：基因治疗是一种有前途的治疗策略，可以从根本上对抗遗传性或后天性疾病，而不仅仅是治疗症状。众所周知，迫切需要无毒且有效的基因递送载体，以充分利用分子医学中基因治疗的当前潜力。生物活性核苷酸的细胞特异性靶向是获得靶组织中治疗功效所需的核酸浓度的先决条件。已经证明许多金属离子，例如Mg2 +，Mn2 +，Ba2 +，最重要的是Ca2 +在基因传递中具有重要作用。这些无机阳离子显示出低毒性，良好的生物相容性并有望实现受控的传递特性，因此为毒性和免疫原性载体提供了新的替代方法。最近，发现单独的无机纳米粒子，或与胶体微粒系统（如纳米脂质体）结合的一种先进的基因传递方法，对基因转移产生了积极的影响。在该报告中，综述了二价阳离子在核酸递送中的作用，特别是在纳米脂质复合物转染效率的潜在改善方面。

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