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首页> 外文期刊>Journal of pharmaceutical sciences. >Penetration of crystalline powder particles into excised human skin membranes and model gels from a supersonic powder injector.
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Penetration of crystalline powder particles into excised human skin membranes and model gels from a supersonic powder injector.

机译：结晶粉末颗粒从超音波粉末注射器渗透到切下的人皮肤膜和模型凝胶中。

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The penetration of crystalline ibuprofen particles into excised human skin membranes and model target gels on actuation with the PowderJect ND1 ballistic needle-free injector has been examined. The deliverable dose of powder exiting the device is approximately 50% of the total cassette loading; the rest is lost via a gap forced open between the injector base and the surface of the target gel. It could be shown that substantial comminution of two different ibuprofen particle size fraction (38-53 microm, 53-75 microm) occurs within the injector on actuation. This resulted in an equiparation of the two initially different size fractions. Reduced comminution occurs with an ibuprofen/PVP (95:5) particulate formed by spray-drying/compaction/milling. On actuation into excised human skin membranes approximately 37% of cassette dose is recovered from the stratum corneum by stripping, and only 3% from the epidermis. It is concluded that powder delivery is mainly intra-epidermal with few particles fully breachingthe stratum corneum. This is a consequence of the relative magnitude of the particle diameter (approximately 48 microm) and the stratum corneum thickness (approximately 10 microm). A 'soft' polyethylene glycol monolayer target gel gives the closest total percentage recovery of powder to that seen with the excised human skin membranes. Bilayer gels differentiated between surface impact/retention and penetration, but were difficult to handle. Powder penetration studies should therefore preferentially to be performed with human skin-membranes. (c) 2006 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 95: 1511-1526, 2006.
机译：已检查了使用PowderJect ND1弹道无针注射器驱动时，结晶的布洛芬颗粒渗透到已切除的人皮肤膜和模型目标凝胶中的情况。离开设备的粉末可输送剂量约为盒总装载量的50％;其余部分则通过在注射器底座和目标凝胶表面之间强制打开的间隙而损失。可以证明，在致动时，在注射器内会发生两种不同的布洛芬粒径分数（38-53微米，53-75微米）的基本粉碎。这导致两个最初不同的尺寸分数相等。通过喷雾干燥/压实/研磨形成的布洛芬/ PVP（95：5）颗粒可减少粉碎。在驱动进入切除的人皮肤膜后，通过剥离从角质层中回收了约37％的盒式剂量，仅从表皮中回收了3％的盒式剂量。结论是粉末输送主要在表皮内，几乎没有颗粒完全穿透角质层。这是粒径（大约48微米）和角质层厚度（大约10微米）的相对大小的结果。 “软”聚乙二醇单层目标凝胶可提供与经切除的人皮肤膜所见最接近的粉末总回收率。双层凝胶在表面冲击/保持力和渗透性之间有区别，但难以处理。因此，粉末渗透性研究应优先对人的皮肤膜进行。 （c）2006 Wiley-Liss，Inc.和美国药剂师协会J Pharm Sci 95：1511-1526，2006。

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