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首页> 外文期刊>Journal of pharmaceutical sciences. >One-Phase Crystal Disorder in Pharmaceutical Solids and Its Implication for Solid-State Stability
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One-Phase Crystal Disorder in Pharmaceutical Solids and Its Implication for Solid-State Stability

机译：药物固体中的单相晶体紊乱及其对固态稳定性的影响

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摘要

Solid-state disorders of active pharmaceutical ingredients have been characterized by means of X-ray diffraction techniques and solid-state nuclear magnetic resonance spectroscopy. The results determined that the pleuromutilin-derivative, I, displays a unique continuous conformational disorder while retaining its long-range crystalline structure. The propionic acid (PA) version of this compound displayed partial crystalline order and site disorder of PA, depending on the quantity of PA incorporated in the structure. Thus, I is a unique example of one-phase crystalline-amorphous model. Physical and chemical stability data was acquired on these disordered systems and discussed in relation with the characterized disorder present in the crystal systems. Analysis of the results showed that in contrast to phase-separated amorphous, restrained disorders do not influence the stability.
机译：借助于X射线衍射技术和固态核磁共振波谱已经表征了活性药物成分的固态病症。结果确定，截短侧耳素衍生物I显示出独特的连续构象障碍，同时保留了其长距离晶体结构。此化合物的丙酸（PA）版本显示PA的部分结晶顺序和位点紊乱，具体取决于结构中掺入的PA的数量。因此，我是一相晶体-非晶模型的独特例子。在这些无序系统上获得了物理和化学稳定性数据，并针对晶体系统中存在的特征性无序进行了讨论。结果分析表明，与相分离的非晶态相反，受约束的紊乱不会影响稳定性。

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