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首页> 外文期刊>Journal of pharmaceutical sciences. >Application of mesoporous silicon dioxide and silicate in oral amorphous drug delivery systems.
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Application of mesoporous silicon dioxide and silicate in oral amorphous drug delivery systems.

机译：中孔二氧化硅和硅酸盐在口服无定形药物递送系统中的应用。

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摘要

Aqueous solubility of an active pharmaceutical ingredient is an important consideration to ensure successful drug development. Mesoporous materials have been investigated as an amorphous drug delivery system owing to their nanosized capillaries and large surface areas. The complex interactions of crystalline compounds with mesoporous media and their implication in drug delivery are not well understood. Molecules interacting with porous media behave very differently than those in bulk phase. Their altered dynamics and thermodynamics play an important role in the properties and product performance of the amorphous system. In this review, application of mesoporous silicon dioxide and silicates in drug amorphization is the main focus. First, as background, the nature of gas-porous media interactions is summarized. The synthesis of various types of mesoporous silica, which are used by many investigators in this field, is described. Second, the behavior of molecules confined in mesopores is compared with those in bulk, crystalline phase. The molecular dynamics of compounds due to confinement, analyzed using various techniques, and their consequences in drug delivery are discussed. Finally, the preparation and performance of drug delivery systems using mesoporous silica are examined.
机译：活性药物成分的水溶性是确保成功开发药物的重要考虑因素。由于介孔材料具有纳米级的毛细管和较大的表面积，因此已作为无定形药物递送系统进行了研究。尚不完全清楚结晶化合物与介孔介质的复杂相互作用及其在药物递送中的含义。与多孔介质相互作用的分子的行为与本体相的行为大不相同。它们改变的动力学和热力学在非晶体系的性质和产品性能中起重要作用。在这篇综述中，介孔二氧化硅和硅酸盐在药物非晶化中的应用是主要焦点。首先，作为背景，总结了气孔介质相互作用的本质。描述了该领域中许多研究人员所使用的各种类型的中孔二氧化硅的合成。其次，将限制在中孔中的分子的行为与本体结晶相的行为进行了比较。讨论了由于限制作用引起的化合物的分子动力学，使用各种技术对其进行了分析，以及它们在药物递送中的后果。最后，研究了使用中孔二氧化硅的药物递送系统的制备和性能。

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