On continuity of integration methods for AUC. A note.

Jawien W

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On continuity of integration methods for AUC. A note.

机译：关于AUC集成方法的连续性。一张纸条。

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摘要

A lack of monotonicity and discontinuity of some integration methods for AUC, as a function of measured concentration, is demonstrated. Hybrid methods consisting of either parabolas-through-the-origin or the alpha-function method followed by the log-trapezoidal method were found to be discontinuous at the switching point. The stable piecewise third-order polynomial method appeared to be nonmonotonic as well as discontinuous.

机译：证明了AUC缺少一些积分方法的单调性和不连续性，这是所测浓度的函数。发现由抛物线穿过原点或alpha函数方法以及对数梯形方法组成的混合方法在切换点不连续。稳定的分段三阶多项式方法似乎既非单调又是不连续的。

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《Journal of pharmacokinetics and biopharmaceutics》 |1998年第1期|共6页
作者
Jawien W;
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正文语种 eng
中图分类药学;
关键词
Area Under Curve; Pharmacokinetics; 曲线下面积; 药代动力学;

机译：Area Under Curve;Pharmacokinetics;曲线下面积;药代动力学;

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On continuity of integration methods for AUC. A note.

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